Pathogenesis and management of nasal polyposis in cystic fibrosis.

Current Allergy and Asthma Reports
J G Mainz, Assen Koitschev

Abstract

Beginning in preschool age, during their lives, up to 50% of cystic fibrosis (CF) patients experience obstructing nasal polyposis (NP), which is rare in non-CF children. Pathogenetic factors of NP in general and especially in CF are still obscure. However, defective epithelial ion transport from mucosal glands plays a central role in CF, and viscous secretions impair mucociliary clearance, promoting chronic pathogen colonization and neutrophil-dominated chronic inflammation. Presently, CF-NP is not curable but can be clinically stabilized, though the large variety of proposed treatment modalities indicates a lack of standardization and of evidence of treatment efficacy. When conservative measures are exhausted, surgical intervention combining individually adapted endoscopic sinus surgery and supportive conservative treatment is performed. Topical steroids, approved as the gold standard for non-CF NP, may be beneficial, but they are discussed to be less effective in neutrophilic inflammation, and CF-specific antimicrobial and mucolytic therapy, as is true of all treatment modalities, urgently requires evaluation by controlled clinical trials within interdisciplinary networks.

References

Apr 11, 1992·The Journal of Pathology·W R Henderson, E Y Chi
May 1, 1992·Archives of Otolaryngology--head & Neck Surgery·J P Cuyler
Aug 1, 1989·The Journal of Laryngology and Otology·A B Drake-Lee, D W Morgan
Dec 1, 1982·American Journal of Diseases of Children·R C SternC F Doershuk
Mar 30, 1995·The New England Journal of Medicine·M W KonstanP B Davis
Oct 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G J NishiokaW E Davis
Jul 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R E Gliklich, R Metson
Sep 1, 1995·The Laryngoscope·S R Hoffman, M C Mahoney
Apr 24, 1993·Lancet·C Koch, N Høiby
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·T Z KhanD W Riches
Apr 1, 1995·The Laryngoscope·T M DavidsonM Light
Nov 1, 1996·Archives of Otolaryngology--head & Neck Surgery·T T KingdomG J Cropp
Mar 1, 1997·The Journal of Infectious Diseases·T L NoahM W Leigh
Apr 1, 1997·The Laryngoscope·A R TalbotD S Parsons
Apr 1, 1997·Clinical Otolaryngology and Allied Sciences·J M Rowe-JonesI S Mackay
Jul 1, 1997·The Laryngoscope·J M Triglia, R Nicollas
Oct 23, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·V J Lund, D W Kennedy
May 30, 1998·Archives of Otolaryngology--head & Neck Surgery·V J LundD H Richards
Oct 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D L HamilosQ Hamid
Dec 16, 1998·The Laryngoscope·D L Schulte, J L Kasperbauer
Mar 6, 1999·Clinical and Diagnostic Laboratory Immunology·J M WolterJ G McCormack
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·M B JorissenH Cuppens
Sep 15, 1999·American Journal of Rhinology·M NonakaT Yagi
Apr 14, 2000·Clinical Otolaryngology and Allied Sciences·P J HadfieldI S Mackay
May 12, 2000·Archives of Otolaryngology--head & Neck Surgery·E M RaynorJ P Bent
Jul 11, 2000·American Journal of Rhinology·T YamadaH Saito
Feb 24, 2001·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G BachmannO Michel
Mar 21, 2002·Clinical Otolaryngology and Allied Sciences·R KayarkarT J Woolford
Dec 25, 2002·The Annals of Otology, Rhinology, and Laryngology·Matthew W YungGraham J G Upton
Feb 28, 2003·Lancet·Felix Ratjen, Gerd Döring
Apr 12, 2003·Clinical Otolaryngology and Allied Sciences·M CimminoV Raia
Oct 2, 2004·The European Respiratory Journal·P-R BurgelJ A Nadel
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Cyrille BergoinBenoît Wallaert
Nov 27, 2004·The Laryngoscope·Peter-John WormaldIan Wong
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S ClaeysC Bachert

❮ Previous
Next ❯

Citations

Dec 7, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Dana L Crosby, Nithin D Adappa
May 6, 2014·International Journal of Pediatric Otorhinolaryngology·Bao Anh Julie DoLily H P Nguyen
May 3, 2014·Pediatrics in Review·Shruti M Paranjape, Peter J Mogayzel
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Mar 16, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Brian D ModenaAndrew A White
Dec 24, 2014·International Forum of Allergy & Rhinology·Jeff Yi-Fu ChenLing-Feng Wang
Dec 23, 2014·International Forum of Allergy & Rhinology·Patrick R StevensGloria Gronowicz
Mar 7, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jochen G MainzJames F Beck
Sep 20, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Natalie BeiersdorfJochen G Mainz
Sep 25, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Domenic VitalMarkus Hofer
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Whitney W StevensAnju T Peters
Jun 17, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·R Rivas Caldas, S Boisramé
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Whitney W StevensRobert C Kern
Sep 23, 2016·Expert Review of Respiratory Medicine·Ruth K MichlJochen G Mainz
May 29, 2013·American Journal of Rhinology & Allergy·Francisco de Borja CallejasJoaquim Mullol
Oct 24, 2015·HNO·J G MainzA Koitschev
Oct 24, 2019·The Cochrane Database of Systematic Reviews·Tulasi Kota KaranthLaxminarayan Karanth
Dec 10, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Michael T Chang, Zara M Patel
Sep 25, 2014·Current Opinion in Pulmonary Medicine·Elisa A Illing, Bradford A Woodworth
Oct 11, 2017·Current Otorhinolaryngology Reports·Kiranya E Tipirneni, Bradford A Woodworth
Mar 1, 2019·Medical Sciences : Open Access Journal·Chetan SafiDavid A Gudis
Apr 26, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Thi Nga NguyenHideaki Suzuki
Jun 20, 2020·International Forum of Allergy & Rhinology·Daniel M BeswickZachary M Soler
Feb 3, 2021·Pediatrics in Review·Kimberly M Dickinson, Joseph M Collaco
Jun 14, 2019·International Journal of Pediatric Otorhinolaryngology·Anne S LoweryFrank W Virgin
Jul 24, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Joanna KrajewskaTomasz Zatoński

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
J G MainzB Tümmler
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Domenic VitalMarkus Hofer
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
J G Mainz, Assen Koitschev
© 2022 Meta ULC. All rights reserved