PMID: 3760265Sep 1, 1986Paper

Pathogenesis and red blood cell destruction in haemoglobinaemic leptospirosis

Journal of Comparative Pathology
J C Thompson, B W Manktelow

Abstract

Sequential morphological changes were seen in RBCs, spleen and liver from hamsters during the development of haemoglobinaemia following infection with Leptospira interrogans serovar ballum. Spleens from pre-haemoglobinaemic hamsters showed sequestration of RBCs and erythrophagocytosis but to a lesser degree than was seen in the haemoglobinaemic hamsters. Erythrophagocytosis and RBC sequestration were also seen in the liver, particularly in the haemoglobinaemic animals. None of these changes was seen in the RBCs, spleens and livers from moribund and dead hamsters suffering from non-haemoglobinaemic disease resulting from infection with Leptospira interrogans serovar pomona. Intracellular leptospires were readily identifiable within the spleens and livers of hamster infected with both ballum and pomona. It is suggested that leptospiral toxins affect RBC metabolism and eventually RBC morphology. The affected cells are detected and removed by the reticulo-macrophage system, usually before intravascular haemolysis can take place. If the toxins affect a certain enzyme or biochemical pathway, there are sufficient normal metabolic differences in RBCs between animals of different species and, in the same species of animal, between the s...Continue Reading

References

May 1, 1976·Journal of Medical Microbiology·R B Marshall
Mar 1, 1986·Veterinary Microbiology·J C Thompson, R B Marshall
Jun 1, 1973·Comparative Biochemistry and Physiology. A, Comparative Physiology·J Zinkl, J J Kaneko
Nov 1, 1966·The American Journal of Medicine·R A Rifkind
Apr 1, 1967·The American Journal of the Medical Sciences·J H Jandl, R H Aster
Jan 1, 1970·The Journal of Cell Biology·A Sengel, P Stoebner
Mar 14, 1968·The New England Journal of Medicine·H S ZarkowskyD G Nathan
Nov 1, 1967·Journal of Dairy Science·R B Johnson, W E Stewart
Sep 1, 1960·The Journal of General Physiology·D C TOSTESON, J F HOFFMAN
Jul 1, 1962·Archives of Internal Medicine·H N WAGNERO T FEAGIN
Nov 1, 1964·American Journal of Veterinary Research·S D SLEIGHTD J STEINBAUER
Aug 1, 1965·The Journal of Experimental Medicine·J H JANDLR A MACDONALD
Feb 28, 1955·The Journal of Physiology·W F WIDDAS

❮ Previous
Next ❯

Citations

Oct 15, 2009·Current Microbiology·Eneas CarvalhoPaulo L Ho
Apr 9, 2001·Clinical Microbiology Reviews·P N Levett
Aug 1, 1989·Journal of Comparative Pathology·J C Thompson, B W Manktelow
Jan 1, 1990·The Korean Journal of Internal Medicine·Y K ParkS K Kang
Jul 9, 2016·PLoS Neglected Tropical Diseases·Heather S HermanJulia L Finkelstein
Aug 15, 2017·The Journal of Small Animal Practice·S KnöpflerB Kohn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.