Pathogenesis and therapeutic strategy in platinum resistance lung cancer.

Biochimica Et Biophysica Acta. Reviews on Cancer
Panpan LvWenyuan Gao

Abstract

Platinum compounds (cisplatin and carboplatin) represent the most active anticancer agents in clinical use both of lung cancer in mono-and combination therapies. However, platinum resistance limits its clinical application. It is necessary to understand the molecular mechanism of platinum resistance, identify predictive markers, and develop newer, more effective and less toxic agents to treat platinum resistance in lung cancer. Here, it summarizes the main molecular mechanisms associated with platinum resistance in lung cancer and the development of new approaches to tackle this clinically relevant problem. Moreover, it could lead to the development of more effective treatment for refractory lung cancer in future.

References

Oct 1, 1996·Immunological Reviews·C A ChambersJ P Allison
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiko IshidaIra Herskowitz
Mar 25, 2005·Nature Reviews. Drug Discovery·Dong Wang, Stephen J Lippard
Jul 30, 2005·Expert Opinion on Investigational Drugs·Kenneth D Tew
Aug 29, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nadja TrillerAndrej Debeljak
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P FanucchiJoan H Schiller
Jan 18, 2007·Archives of Pharmacal Research·Min-Koo Choi, Dae-Duk Kim
Feb 24, 2007·Cancer Metastasis Reviews·Macus Tien KuoToshihisa Ishikawa
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Nov 17, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hak-Ryul KimRaekil Park
Apr 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anuj AgarwalaNasser Hanna
Aug 1, 2008·BMC Cancer·Francesca RussoUNKNOWN Investigators of Italian Pemetrexed Monotherapy of NSCLC Group
Dec 17, 2008·Clinical Lung Cancer·Sumanta Kumar PalKaren L Reckamp
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John R EckardtHazel B Breitz
Aug 12, 2009·Journal of Experimental & Clinical Cancer Research : CR·Hecheng LiHaiquan Chen
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shadia JalalNasser Hanna
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Wenshu ChenYong Lin
Apr 23, 2011·Nature·Michele De Palma, Claire E Lewis
Jun 15, 2011·Cancer Letters·Christoph WohlkoenigHorst Olschewski
Jul 27, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Helen H W ChenWu-Chou Su
Nov 26, 2011·Cell Death and Differentiation·M BartucciR De Maria
Dec 14, 2011·Oncology Reports·Šimon CiproTomáš Eckschlager
Jan 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hirohito YamaguchiMien-Chie Hung
May 30, 2013·Trends in Molecular Medicine·Hannelore MaesPatrizia Agostinis
Jun 19, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Denise A Yardley
Aug 27, 2013·Cancer Chemotherapy and Pharmacology·Kyriakos P PapadopoulosJeffery R Infante
Sep 21, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Francesca MazzoniFrancesco Di Costanzo
Oct 15, 2013·Therapeutic Delivery·Karim Y HelmyPranela Rameshwar
Mar 22, 2014·Biochemical Society Transactions·Naila Rabbani, Paul J Thornalley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Eric S KimZ H Siddik
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P TothillJ F Smyth
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Roman P Wernyj, Patrice J Morin
Anti-cancer Agents in Medicinal Chemistry
Rajiv SharmaPooja A Chawla
© 2021 Meta ULC. All rights reserved