Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020.

International Archives of Allergy and Immunology
Malgorzata BobrowiczEmmanuella Guenova

Abstract

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology with a complex immunological background. As CTCL arises from T cells that have a vital role in the antitumor response, their therapy is largely aimed at reversing the immunological mechanisms leading to or manifesting during this malignancy. Early disease stages can be controlled with skin-directed therapy in most CTCL cases. Still, advanced CTCL has a dismal prognosis and warrants systemic therapy. Despite considerable progress in understanding the pathophysiology of the disease and the numerous systemic treatment options available, long-term remission rates with conventional treatments alone are still low. Allogeneic hematopoietic stem cell transplantation is currently the only curative option for advanced CTCL, including mycosis fungoides and Sézary syndrome. The aims of this review is to summarize the recent findings on the immunology of this heterogeneous disease and to present the advances in its clinical management.

References

Jan 1, 1992·The Journal of Investigative Dermatology·Y TokuraR L Edelson
Feb 7, 1990·Journal of the National Cancer Institute·E H KaplanP A Bunn
Oct 18, 1989·Journal of the National Cancer Institute·A S WhittemoreC Gibney
Nov 1, 1994·The Journal of Investigative Dermatology·B R VowelsA H Rook
Sep 1, 1996·The Journal of Investigative Dermatology·C M JackowM Duvic
Oct 31, 1996·Annals of the New York Academy of Sciences·A H RookG Trinchieri
Jul 2, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Reinhard DummerGünter Burg
Jun 19, 2004·The Journal of Dermatological Treatment·A ChongP G Norris
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Oct 30, 2004·Blood·Carole L BergerRichard L Edelson
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith B GordenJohn P Vasilakos
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Feb 5, 2005·Journal of the American Academy of Dermatology·Matthew J DeethsJohn L Aeling
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Deborah S GoddardDavid A Jones
Dec 16, 2005·The Journal of Investigative Dermatology·Jean-David BouazizArmand Bensussan
Jun 3, 2006·The Journal of Investigative Dermatology·Machteld M TiemessenSusan John
Feb 16, 2007·The British Journal of Dermatology·L Y T Chiam, Y C Chan
May 21, 2008·Archives of Dermatology·Emmanuella GuenovaMartin Rocken
Jan 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Noriko KomatsuShohei Hori
Feb 25, 2009·British Journal of Haematology·Liuyan JiangMaryalice Stetler-Stevenson
Jul 25, 2009·The Journal of Investigative Dermatology·Julia B HeidClaus-Detlev Klemke
Aug 14, 2009·The Journal of Investigative Dermatology·Rachael A Clark
Dec 17, 2009·American Journal of Clinical Dermatology·Dorothea TerhorstMartin Mempel
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Dagmar von BubnoffJacques Zimmer
Feb 5, 2010·The Journal of Investigative Dermatology·Elodie LaharanneJean-Philippe Merlio
Mar 17, 2010·The Journal of Investigative Dermatology·Emmanuel Contassot, Lars E French
May 15, 2010·Journal of the American Academy of Dermatology·Christoph SchlapbachNikhil Yawalkar
Feb 18, 2011·American Journal of Hematology·David A WadaNneka I Comfere
Feb 25, 2011·Future Oncology·Cori MorrisonEduardo Davila

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Citations

Mar 2, 2021·Frontiers in Medicine·Kenji Kabashima, Hiroyuki Irie
Aug 28, 2021·Nature Reviews. Disease Primers·Reinhard DummerEgle Ramelyte
Sep 15, 2021·The British Journal of Dermatology·I Pospischil, E Guenova
Sep 21, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Constanze JonakEmmanuella Guenova
Sep 21, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Constanze JonakEmmanuella Guenova

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