Pathogenesis and transmission of SARS-CoV-2 in golden hamsters.

Sin Fun SiaHui-Ling Yen


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect on healthcare systems and economies1,2. A suitable small animal model is needed to support the development of vaccines and therapies. Here we report the pathogenesis and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters (Mesocricetus auratus). Immunohistochemistry assay demonstrated the presence of viral antigens in nasal mucosa, bronchial epithelial cells and areas of lung consolidation on days 2 and 5 after inoculation with SARS-CoV-2, followed by rapid viral clearance and pneumocyte hyperplasia at 7 days after inoculation. We also found viral antigens in epithelial cells of the duodenum, and detected viral RNA in faeces. Notably, SARS-CoV-2 was transmitted efficiently from inoculated hamsters to naive hamsters by direct contact and via aerosols. Transmission via fomites in soiled cages was not as efficient. Although viral RNA was continuously detected in the nasal washes of inoculated hamsters for 14 days, the communicable period was short and correlated with the dete...Continue Reading


Jan 1, 1982·Archives of Virology·M J AliC W Potter
Jun 1, 1964·The Journal of Infectious Diseases·D A BUTHALA, M G SORET
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·William G GlassPhilip M Murphy
Dec 15, 2004·Journal of Virology·Anjeanette RobertsKanta Subbarao
Mar 26, 2005·The EMBO Journal·Wenhui LiMichael Farzan
May 15, 2007·Virus Research·Anjeanette RobertsKanta Subbarao
Feb 22, 2011·Journal of Immunological Methods·Marko ZivcecHideki Ebihara
Aug 2, 2013·Future Microbiology·Jessica A BelserTerrence M Tumpey
Mar 31, 2015·Journal of Occupational and Environmental Medicine·Rachael M Jones, Lisa M Brosseau
Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Vineet D MenacheryRalph S Baric
Oct 11, 2016·Advances in Experimental Medicine and Biology·Bryce M WarnerGary P Kobinger
Oct 22, 2019·Frontiers in Immunology·Jinxin MiaoYaohe Wang
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 8, 2020·Clinical Chemistry·Daniel K W ChuLeo L M Poon
Mar 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jasper Fuk-Woo ChanKwok-Yung Yuen
Apr 17, 2020·Nature Medicine·Xi HeGabriel M Leung
May 8, 2020·Nature·Linlin BaoChuan Qin
May 13, 2020·Nature·Vincent J MunsterEmmie de Wit
Jun 27, 2020·Obstetrics and Gynecology·Ilia Bresesti, Lorella Rossi

❮ Previous
Next ❯


May 29, 2020·Journal of Medical Virology·Nevio Cimolai
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
Aug 5, 2020·The Journal of Experimental Medicine·Benjamin IsraelowAkiko Iwasaki
Aug 5, 2020·Emerging Infectious Diseases·Ranawaka A P M PereraMalik Peiris
Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Sep 12, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rafal Butowt, Christopher S von Bartheld
Sep 9, 2020·Emerging Microbes & Infections·Tingting LiNingshao Xia
Sep 27, 2020·MBio·Chengjin YeLuis Martinez-Sobrido
Sep 29, 2020·Scientific Reports·Greg N Brooke, Filippo Prischi
Sep 25, 2020·Current Opinion in HIV and AIDS·Xin LiJasper Fuk-Woo Chan
Sep 24, 2020·Nature·Florian Krammer
Sep 29, 2020·Frontiers in Immunology·Inmaculada Sanclemente-AlamanUlises Gómez-Pinedo
Sep 5, 2020·Nature Medicine·Lisa H TostanoskiDan H Barouch
Jun 20, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Nadia OreshkovaArjan Stegeman
Jun 20, 2020·GeroScience·Brandt D Pence
Aug 13, 2020·Nature Reviews. Immunology·Stylianos BournazosJeffrey V Ravetch
Jul 24, 2020·Viruses·Nikolaus OsterriederJakob Trimpert
Aug 12, 2020·Briefings in Bioinformatics·Zulkar NainMohammad Ali Moni
Jul 14, 2020·Frontiers in Immunology·Marisa MarketRebecca C Auer
Sep 27, 2020·Xenotransplantation·Tanja Opriessnig, Yao-Wei Huang
Sep 6, 2020·Disease Models & Mechanisms·Sarah R LeistDavid R Martinez
Oct 1, 2020·Scientific Reports·Yuan ZhaoXiaozhong Peng
Jul 16, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna Jinxia ZhangKwok-Yung Yuen
Jul 24, 2020·Microbial Biotechnology·Sophie Zuber, Harald Brüssow
Oct 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Salleh N EhaidebAbderrezak Bouchama
Oct 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chanu RheeMichael Klompas
Sep 25, 2020·Journal of Neurochemistry·Isaias GlezerBettina Malnic
Aug 28, 2020·Nature·Kenneth H DinnonRalph S Baric
Oct 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Suzanne J F KapteinLeen Delang
Oct 3, 2020·Emerging Microbes & Infections·David A MeekinsJuergen A Richt
Sep 24, 2020·Nature·César Muñoz-FontelaDan H Barouch
Oct 21, 2020·Nature Reviews. Materials·Zhongmin TangWei Tao
Oct 22, 2020·Biochemical Society Transactions·Zhongyi WangQiang Sun
Oct 10, 2020·Transboundary and Emerging Diseases·Wendy K JoJan Felix Drexler
Oct 25, 2020·BMJ : British Medical Journal·Muge CevikMalik Peiris
Nov 4, 2020·British Journal of Pharmacology·Simon J ClearyClive P Page

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned

GraphPad Prism
Leica Application Suite

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved