Pathogenesis, clinical manifestations and management of immune checkpoint inhibitors toxicity

Tumori
Alessandro InnoStefania Gori

Abstract

Immune checkpoint inhibitors have emerged as an effective treatment for several tumor types and their use in clinical practice is expected to further increase in the immediate future. Although these agents are well tolerated, they are associated with a peculiar spectrum of toxicity, which is immune mediated and may potentially affect every organ. However, immune-related adverse events are mostly reversible if promptly diagnosed and adequately treated. Therefore, it is crucial that medical oncologists know how to diagnose and treat immune-related adverse events. This review focuses on the pathogenesis, clinical manifestations and management of immune-related toxicity of anti-CTLA-4 and anti-PD-1 antibodies.

References

Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
Aug 2, 2003·Biochemical and Biophysical Research Communications·Pornpan YoungnakMiyuki Azuma
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Mar 24, 2004·Seminars in Immunology·Ciriaco A Piccirillo, Ethan M Shevach
May 4, 2004·Nature Reviews. Immunology·Lieping Chen
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KonishiMasaharu Nishimura
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Nov 10, 2004·Journal of Immunotherapy·Michael R RobinsonSteven A Rosenberg
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuichiro OhigashiYoshiyuki Nakajima
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter AttiaSteven A Rosenberg
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly E BeckJames C Yang
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takeo NomiYoshiyuki Nakajima
Nov 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie G DowneySteven A Rosenberg
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
May 27, 2008·Nature Reviews. Immunology·Weiping Zou, Lieping Chen
Sep 2, 2008·Immunological Reviews·Brian T Fife, Jeffrey A Bluestone
Oct 4, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·A EckertL Thomas
Nov 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberEvan Hersh
Dec 5, 2008·Cancer Immunology, Immunotherapy : CII·Ilyssa O GordonThomas F Gajewski
Feb 27, 2009·Journal of Immunotherapy·Mojtaba AkhtariMartha L Arellano
May 12, 2009·Immunological Reviews·Roza I NurievaChen Dong
Jul 10, 2009·The New England Journal of Medicine·Fouad FadelBertrand Knebelmann
Feb 12, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J O'DayJ D Wolchok
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katarzyna D ChmielRichard Kefford
Feb 1, 2011·Annals of the New York Academy of Sciences·Brian T Fife, Kristen E Pauken
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Aug 3, 2011·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·S AhmadM Iddawela
Nov 4, 2011·The New England Journal of Medicine·Julie DelyonThierry Lambert
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wouter V VogelChristian U Blank
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff

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Citations

Oct 31, 2019·Immunotherapy·Francesco MassariAntonio Lopez-Beltran
Sep 19, 2019·Journal of Current Ophthalmology·Tony FangMahyar Etminan
Jul 29, 2020·Current Treatment Options in Oncology·Puneet SaxenaNavneet Singh
Aug 25, 2020·Journal of Immunology Research·Yan XiaoWeirong Yao
Feb 21, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Evelyn WangDonald Y M Leung
Apr 21, 2021·Cancer Immunology, Immunotherapy : CII·Alessandro InnoStefania Gori
May 27, 2020·Journal of the American Academy of Dermatology·Amaris N GeislerMario E Lacouture
Jun 15, 2021·Frontiers in Cardiovascular Medicine·Alessandro InnoStefania Gori
Aug 4, 2021·Critical Reviews in Oncology/hematology·Alessandro InnoFausto Petrelli
Aug 29, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Bellinda L King-KallimanisPaul G Kluetz
Sep 12, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David J PinatoLorraine Pelosof
Oct 30, 2021·CA: a Cancer Journal for Clinicians·Sharon EladStephen T Sonis

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Methods Mentioned

BETA
hormone replacement therapy
biopsy
bronchoalveolar lavage
hormone replacement

Clinical Trials Mentioned

NCT02156804

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