Pathogenesis, diagnostic challenges and treatment of zika virus disease in resource-limited settings

The Nigerian Postgraduate Medical Journal
Nathan Yakubu ShehuDaniel Z Egah

Abstract

The association of Zika virus (ZIKV) infection with congenital malformation and neurological sequelae has brought significant global concern. Consequently, the World Health Organization (WHO) declared it "a public health emergency of International concern" on 1 February, 2016. A critical review of its pathogenesis would lead to a better understanding of the clinical features and the neurological complications. This review is based on literature search in PubMed/Medline, Google Scholar and the WHO, http://www.who.int. This include all relevant articles written in English published through June 2018, with subject heading and keywords such as Zika, ZIKV, Zika pathogenesis, diagnosis of Zika, Zika Nigeria, Zika Africa and Zika resource-limited settings. Following ZIKV infection, viraemia ensues targeting primarily the monocytes for both the Asian and African strains. ZIKV infection by an African strain appears to be more pathogenic, in early pregnancy tends to result in spontaneous abortion. Whereas an Asian strain tends to be less pathogenic and more chronic, this allows the pregnancy to continue, ultimately resulting in congenital malformations. There is no routine laboratory diagnosis of ZIKV infection in resource-constrained co...Continue Reading

References

Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Aug 8, 2017·International Journal of Molecular Sciences·Antonio Victor Campos Coelho, Sergio Crovella

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Citations

Sep 27, 2020·Tropical Medicine and Infectious Disease·Nelly M SilvaIvo C Martins
May 31, 2019·Frontiers in Immunology·Mariah HassertAmelia K Pinto

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