PMID: 2122875Jan 1, 1990Paper

Pathogenesis of a phleboviral infection (Punta Toro virus) in golden Syrian hamsters

Archives of Virology
G W AndersonC J Peters

Abstract

The hamster, Mesocricetus auratus, was examined as a possible model for investigating the poorly defined pathogenesis of the family Bunyaviridae, genus Phlebovirus. Punta Toro virus (PTV) isolates from Eastern Panama were highly virulent for two outbred and five inbred hamster strains, while isolates from western Panama were of low virulence. The Adames strain (eastern Panama) of PTV (LD50 approximately 1 PFU, sc) caused an acute fatal disease (average survival time, 3.8 days) in 10-week-old Lak: LVG (SYR) hamsters. Severe necrosis of the liver, spleen, and small intestine was associated with extensive expression of viral antigen in these organs. The Balliet strain (western Panama) of PTV (LD50 greater than 6 log10 PFU, subcutaneously) caused a mild hepatocellular infection with peak viral liver titers of 3-4 log10 PFU/g compared to 8-9 log10 PFU/g for the Adames strain. We observed histological lesions in the red pulp of the spleen or the lamina propria of the small intestine with the Adames strain. Lesions in the hamsters had characteristics of disseminated intravascular coagulation (DIC). The PTV-hamster model shares similarities to Rift Valley fever (phleboviral disease), which causes fatal disease in man and domesticated r...Continue Reading

References

Dec 1, 1987·Microbial Pathogenesis·D Y Pifat, J F Smith
May 1, 1989·Reviews of Infectious Diseases·T M CosgriffC J Peters
Jan 1, 1988·Archives of Virology·G W AndersonC J Peters
Oct 1, 1988·Microbial Pathogenesis·G W Anderson, C J Peters
Jan 1, 1988·Archives of Virology·C J PetersT W Slone
Apr 1, 1987·Microbial Pathogenesis·G W AndersonC J Peters
Mar 1, 1974·The American Journal of Tropical Medicine and Hygiene·R B TeshK M Johnson

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Citations

Jul 4, 2007·Antimicrobial Agents and Chemotherapy·Brian B GowenRobert W Sidwell
May 26, 2006·Antimicrobial Agents and Chemotherapy·Brian B GowenRobert W Sidwell
Dec 14, 2011·Journal of Virology·Darci R SmithLisa E Hensley
Jun 15, 2011·Viruses·Tetsuro Ikegami, Shinji Makino
Dec 3, 2014·Antiviral Research·Darci R SmithBrian B Gowen
Nov 17, 2011·Virus Research·Ted M RossDarci R Smith
Nov 27, 2007·Antiviral Research·Brian B Gowen, Michael R Holbrook
Sep 21, 2010·Virology·Darci R SmithLisa E Hensley
Apr 20, 2012·The Journal of General Virology·Emna Ayari-FakhfakhCatherine Cêtre-Sossah
Feb 16, 2011·Virus Research·Shanna L AshleyKatherine R Spindler
Jan 22, 2015·PloS One·Dionna SchartonBrian B Gowen
Jun 25, 2016·Viruses·Jennifer Deborah Wuerth, Friedemann Weber
Dec 1, 2009·Viruses·Richard M Elliott, Friedemann Weber
Jun 11, 2005·American Journal of Respiratory Cell and Molecular Biology·Adriana Vieira-de-AbreuPatrícia T Bozza
Mar 11, 2009·Reviews in Medical Virology·Carla ArpinoGiovanni Rezza
Oct 22, 2019·Frontiers in Immunology·Jinxin MiaoYaohe Wang
Mar 1, 2017·The Journal of Microbiology·Brian B Gowen, Brady T Hickerson
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian B GowenRobert W Sidwell

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