PMID: 9655477Jul 9, 1998Paper

Pathogenesis of acute passive murine encephalomyelitis I. Importance of host-derived cells as determined by kinetic analysis

Journal of Neuroimmunology
J A LyonsR B Fritz

Abstract

Kinetics of entry into the CNS of donor- and host-derived T-cells during the onset of acute murine EAE induced by the passive transfer of an encephalitogenic PLP(139-151)-specific T-cell clone was investigated. RT-PCR and spectratypic analysis of total RNA recovered from recipient mice demonstrated the presence in the CNS of donor- and host-derived T-cells 24 h post adoptive transfer. Donor-derived T-cells detected in the CNS decreased days 2-6 post transfer while host-derived T-cells persisted during this time. Beginning 3 days before clinical onset, an increase in the CNS of both T-cell populations was observed which persisted through disease onset. Similar analysis performed on recipients of an nonencephalitogenic PLP(139-151)-specific T-clone demonstrated a transient infiltration of donor- and host-derived T-cells beginning 4 days post transfer (dpt) and returning to background levels by day 7 post transfer. Results presented here suggest the importance of host-derived T-cells in the onset of acute passive murine EAE.

References

Oct 1, 1992·European Journal of Immunology·M CochetP Kourilsky
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Aug 4, 1988·Nature·M M Davis, P J Bjorkman
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Jun 1, 1994·Current Opinion in Neurology·R M RansohoffP Lehmann
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C PannetierP Kourilsky
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Steinman
Jan 1, 1960·The Journal of Experimental Medicine·P Y PATERSON

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Citations

Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R B FritzM L Zhao

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