Pathogenesis of acute renal failure following temporary renal ischemia in the rat.

Circulation Research
W J ArendshorstC W Gottschalk

Abstract

In this study, we characterized the sequence of several intrarenal events and evaluated their relative importance in the pathogenesis of unilateral oliguric acute renal failure induced experimentally in rats by complete occlusion of a renal artery for 1 hour. Kidneys were studied prior to occlusion and 1-3 hours and 22-26 hours after release of the temporary occlusion. Renal blood flow measured by an electromagnetic flow transducer was reduced to 40-50% of control during both postocclusion periods. Flow of tubular fluid was markedly reduced, and the damaged kidneys were oliguric. Proximal and distal convolutions were filled with fluid and dilated 1-3 hours after occlusion; their pressures were greatly heterogeneous and were elevated, on the average, to 31 and 16 mm Hg, respectively. Glomerular capillary pressure at this time was normal or slightly increased. Histological sections showed extensive tubular obstruction. We conclude that initially the oliguria is primarily due to intraluminal obstruction in the absence of predominant increases in preglomerular vascular resistance. Observations at 22-26 hours after occlusion indicated acute tubular necrosis. Moreover, the combined involvement of preglomerular vasoconstriction, presi...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Investigation·R C Blantz
Jan 1, 1975·The American Journal of Physiology·W J ArendshorstC W Gottschalk
Dec 1, 1973·Kidney International·G A TannerS Sophasan
Jan 1, 1974·The Journal of Clinical Investigation·T M DaughartyB M Brenner
May 1, 1974·The Journal of Clinical Investigation·W J ArendshorstC W Gottschalk
Jun 1, 1974·The Journal of Clinical Investigation·J W CoxT F Ferris
Jan 1, 1972·The Journal of Clinical Investigation·J FloresA Leaf
Oct 1, 1972·The American Journal of Physiology·M E AllisonC W Gottschalk
May 1, 1968·The American Journal of Medicine·T U BiberM C MacDowell

❮ Previous
Next ❯

Citations

Jan 1, 1995·Urological Research·M C ReganJ M Fitzpatrick
Jan 1, 1996·Urological Research·L S YoungJ M Fitzpatrick
Nov 1, 1990·Pflügers Archiv : European journal of physiology·J M Davis
Oct 19, 1977·Pflügers Archiv : European journal of physiology·H OsswaldR Kemper
Dec 1, 1981·Pflügers Archiv : European journal of physiology·J MasonJ Schnermann
Aug 1, 1979·Pflügers Archiv : European journal of physiology·N S FregaA Leaf
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·T S OlsenH S Olsen
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J E Bird, R C Blantz
Dec 15, 1991·Klinische Wochenschrift·M WolgastG Ojteg
Aug 1, 1982·Klinische Wochenschrift·H von GiseE Mickeler
Jan 6, 2010·Intensive Care Medicine·Takao SaotomeRinaldo Bellomo
Feb 9, 1993·European Journal of Pharmacology·D Pruneau, P Bélichard
Apr 20, 1996·Journal of the Autonomic Nervous System·C T ChienC F Chen
May 18, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Göksel SenerAbdullah Sakarcan
Jan 1, 1983·Experimental Pathology·J BrzozowskiJ Ostapowicz
Nov 30, 2000·Anesthesiology Clinics of North America·R N Sladen
Jun 23, 1977·The New England Journal of Medicine·N G Levinsky
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J I KreisbergA Leaf
Jan 1, 1990·Acta Physiologica Scandinavica·A BayatiM Wolgast
Mar 24, 2012·American Journal of Physiology. Renal Physiology·David P BasileJessica Friedrich
Mar 19, 2005·Nephron. Experimental Nephrology·Yoshihiro KudoTetsuro Sugiura
Dec 1, 1989·The Journal of Clinical Investigation·A I Wolfert, D E Oken
Jan 24, 2012·Journal of the American Society of Nephrology : JASN·Prabhleen SinghScott C Thomson
May 20, 2008·Molecular Medicine·Matthieu LegrandCan Ince
Oct 27, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·H D ZimmermannP Dieker
Dec 12, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·M SteinhausenA Schwaier
May 26, 2005·Radiology·Richard W Katzberg
Oct 1, 1977·Environmental Health Perspectives·W F Finn
Jan 1, 1982·Scandinavian Journal of Urology and Nephrology·L KarlbergM Wolgast
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S N Rahman, J D Conger
Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S A FalkJ D Conger
May 1, 1993·Kidney International·J V Bonventre
Jul 1, 1983·Kidney International·J MasonT Takabatake

❮ Previous
Next ❯

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