Pathogenesis of age-related HIV neurodegeneration

Journal of Neurovirology
Miroslaw Mack MackiewiczE Masliah

Abstract

People over the age of 50 are the fastest growing segment of the HIV-infected population in the USA. Although antiretroviral therapy has remarkable success controlling the systemic HIV infection, HIV-associated neurocognitive disorder (HAND) prevalence has increased or remained the same among this group, and cognitive deficits appear more severe in aged patients with HIV. The mechanisms of HAND in the aged population are not completely understood; a leading hypothesis is that aged individuals with HIV might be at higher risk of developing Alzheimer's disease (AD) or one of the AD-related dementias (ADRD). There are a number of mechanisms through which chronic HIV disease alone or in combination with antiretroviral therapy and other comorbidities (e.g., drug use, hepatitis C virus (HCV)) might be contributing to HAND in individuals over the age of 50 years, including (1) overlapping pathogenic mechanisms between HIV and aging (e.g., decreased proteostasis, DNA damage, chronic inflammation, epigenetics, vascular), which could lead to accelerated cellular aging and neurodegeneration and/or (2) by promoting pathways involved in AD/ADRD neuropathogenesis (e.g., triggering amyloid β, Tau, or α-synuclein accumulation). In this manuscr...Continue Reading

References

May 1, 1995·Journal of Neuropathology and Experimental Neurology·E MasliahC A Wiley
Dec 15, 1994·Annals of the New York Academy of Sciences·S A Lipton
Nov 9, 2002·The Journal of Infectious Diseases·Avi Nath
Dec 25, 2003·Lancet Neurology·Ian McKeithUNKNOWN International Psychogeriatric Association Expert Meeting on DLB
Apr 13, 2004·Oncogene·Devrim Gozuacik, Adi Kimchi
Apr 23, 2004·Trends in Cell Biology·Ana Maria Cuervo
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Jan 26, 2005·AIDS·Hans C Rempel, Lynn Pulliam
Mar 9, 2005·Journal of Neuropathology and Experimental Neurology·Ralph A NixonAna Maria Cuervo
Nov 2, 2005·Neurotoxicity Research·I P EverallE Masliah
Dec 15, 2005·Journal of Virology·Deborah Carroll-Anzinger, Lena Al-Harthi
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor Valcour, Robert Paul
Aug 1, 2006·Journal of Neurovirology·Abigail DailyLouis B Hersh
Dec 21, 2006·Nature Reviews. Neuroscience·Ronald EllisEliezer Masliah
Sep 12, 2007·Journal of Neuroscience Research·Italo MocchettiEliezer Masliah
Apr 22, 2008·Autophagy·Stephen A Spector, Dejiang Zhou
Nov 20, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jiqing Xu, Tsuneya Ikezu
Dec 31, 2008·Journal of Neurovirology·Negar KhanlouUNKNOWN HNRC Group
Jan 14, 2009·Acta Neuropathologica·Tetsuaki AraiHaruhiko Akiyama
Mar 17, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Lynn Pulliam
Mar 17, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Cristian L AchimUNKNOWN Neurobehavioral Research Center
Apr 29, 2009·International Journal of Molecular Sciences·Leslie CrewsEliezer Masliah
Jul 29, 2009·The Journal of Cell Biology·George B KyeiVojo Deretic
Dec 26, 2009·The American Journal of Pathology·Trung P NguyenBenjamin B Gelman
Feb 24, 2010·Journal of Neurovirology·I EverallUNKNOWN National NeuroAIDS Tissue Consortium (NNTC)
Mar 30, 2010·Journal of Neurovirology·John A JoskaAlan J Flisher
Apr 24, 2010·Human Molecular Genetics·Leslie Crews, Eliezer Masliah
Sep 25, 2010·AIDS and Behavior·J Cobb ScottUNKNOWN HIV Neurobehavioral Research Center (HNRC) Group
Oct 13, 2010·Archives of Neurology·Philipp A Jaeger, Tony Wyss-Coray

❮ Previous
Next ❯

Citations

Sep 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rowan SalonerUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Nov 3, 2020·Frontiers in Cellular and Infection Microbiology·Caitlin TiceDianne Langford
Jul 21, 2020·International Journal of Nursing Sciences·Chang GaoHonghong Wang
Feb 28, 2021·Neurology·Yair MinaUNKNOWN NIH-DOD NeuroHIV Consortium
Jul 10, 2021·Frontiers in Neurology·Antonio Spagnolo-Allende, Jose Gutierrez
Jan 6, 2022·Clinical Science·Manon Chauvin, Delphine Sauce

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
transgenic

Related Concepts

Related Feeds

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.