Pathogenesis of and management strategies for postoperative delirium after hip fracture: a review

Acta Orthopaedica Scandinavica
Martin BitschHenrik Kehlet

Abstract

Postoperative delirium is a frequent and serious complication in elderly patients following operation for hip fracture, leading to an increased risk of complications. The pathophysiological mechanisms are unresolved, but probably multifactorial. The purpose of this review is to summarize current knowledge about the pathogenesis of postoperative delirium with a view to finding strategies for prevention and management. We conducted an Internet search through the Medline database (1966-March 2003) and supplemented it with a manual search. We included 12 studies which specifically discussed pathogenic factors or interventions against postoperative delirium following operation for hip fracture. 1,823 patients were included with an average incidence of delirium of 35%. We concentrated on pre-, intra-, and postoperative risk factors. Only advanced age and dementia met our fixed criterion of "strong evidence" for a significant association. Hence, from the studies that we reviewed we were unable to find intraoperative or postoperative factors with "strong evidence" for a significant association with delirium. Postoperative delirium is a serious complication. The pathophysiology leading to delirium after hip fracture surgery still remain...Continue Reading

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