Pathogenesis of atherosclerosis

Journal of the American College of Cardiology
Erling Falk

Abstract

Atherosclerosis is a multifocal, smoldering, immunoinflammatory disease of medium-sized and large arteries fuelled by lipids. Endothelial cells, leukocytes, and intimal smooth muscle cells are the major players in the development of this disease. The most devastating consequences of atherosclerosis, such as heart attack and stroke, are caused by superimposed thrombosis. Therefore, the vital question is not why atherosclerosis develops but rather why atherosclerosis, after years of indolent growth, suddenly becomes complicated with luminal thrombosis. If thrombosis-prone plaques could be detected and thrombosis averted, atherosclerosis would be a much more benign disease. Approximately 76% of all fatal coronary thrombi are precipitated by plaque rupture. Plaque rupture is a more frequent cause of coronary thrombosis in men (approximately 80%) than in women (approximately 60%). Ruptured plaques are characterized by a large lipid-rich core, a thin fibrous cap that contains few smooth muscle cells and many macrophages, angiogenesis, adventitial inflammation, and outward remodeling. Plaque rupture is the most common cause of coronary thrombosis. Ruptured plaques and, by inference, rupture-prone plaques have characteristic pathoanato...Continue Reading

References

May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Sep 19, 1998·Journal of the American College of Cardiology·M KaartinenP T Kovanen
Dec 21, 2000·Current Atherosclerosis Reports·S M SchwartzM E Rosenfeld
Mar 10, 2001·Cell·C K Glass, J L Witztum
Aug 31, 2001·Journal of the American College of Cardiology·A VinkG Pasterkamp
Dec 4, 2002·Circulation·Takahiko NarukoAnton E Becker
Dec 20, 2002·Nature·Peter Libby
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Apr 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Noel M CapliceWilliam D Edwards
Jun 28, 2003·BMJ : British Medical Journal·N J Wald, M R Law
Oct 29, 2003·Circulation·James T Willerson, Dean J Kereiakes
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Steven E NissenRichard Kerensky
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaime LlodráGwendalyn J Randolph
Aug 24, 2004·Current Vascular Pharmacology·Jinho ShinMun K Hong
Oct 21, 2004·JAMA : the Journal of the American Medical Association·Luigi Giusto SpagnoliDavid R Holmes
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jun 3, 2005·American Journal of Human Genetics·Xiaosong WangBeverly Paigen
Jun 25, 2005·Circulation Research·Gary F Lewis, Daniel J Rader

❮ Previous
Next ❯

Citations

Dec 2, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·G van SoestA F W van der Steen
Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stéphane G CarlierGregg W Stone
Sep 11, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sergio WaxmanJay D Caplan
May 18, 2013·The Proceedings of the Nutrition Society·A David Marais
Nov 29, 2012·European Journal of Clinical Nutrition·C M RebholzJ He
Oct 22, 2011·Nature Reviews. Drug Discovery·Mark E LobattoWillem J M Mulder
Nov 1, 2011·Physics in Medicine and Biology·M S Richards, M M Doyley
Jun 2, 2012·Cardiovascular Research·Mette K HagensenJacob F Bentzon
Jan 27, 2012·European Heart Journal Cardiovascular Imaging·Francis R JoshiJames H F Rudd
Jul 2, 2011·European Heart Journal·P J de Feijter, K Nieman
Dec 18, 2012·European Heart Journal·Erling FalkRenu Virmani
Jun 7, 2012·Interface Focus·David Gomez-CabreroJesper Tegner
Nov 26, 2010·Clinical and Experimental Pharmacology & Physiology·Tarik SmaniAntonio Ordóñez
Jan 26, 2012·Thrombosis and Haemostasis·Sébastien LengletFabrizio Montecucco
Feb 16, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Amanda C DoranColeen A McNamara
Oct 8, 2009·Circulation. Cardiovascular Imaging·Lynne WagenknechtEric Boerwinkle
Jan 29, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Steen F PedersenWon Y Kim
Sep 23, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Steen Fjord PedersenWon Yong Kim
Jun 14, 2013·Clinical Interventions in Aging·Xavier Castellon, Vera Bogdanova
Jul 17, 2008·Vascular Health and Risk Management·Deirdre F WaterhouseCj McCreery
Oct 11, 2012·Vascular Health and Risk Management·Atul Ashok KalanuriaGeoffrey Ling
Feb 24, 2009·AJR. American Journal of Roentgenology·Harald BrodoefelMelvin E Clouse
Jun 5, 2012·Journal of the American Veterinary Medical Association·Anthony A PilnyRoy D Berghaus
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·David C SaneCharles S Greenberg
Nov 29, 2013·International Journal of Molecular Sciences·Mei-Hua BaoHong-Hao Zhou
Oct 26, 2012·Journal of Geriatric Cardiology : JGC·Graziano Riccioni, Valeriana Sblendorio
Aug 1, 2007·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tim J L Van De ParreGuido R Y De Meyer
Dec 30, 2008·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dolf SegersJon D Laman
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Juan F GranadaErling Falk
Dec 7, 2013·Theranostics·Hakan OrbayWeibo Cai
Apr 12, 2014·Theranostics·Amanda Karine Andriola SilvaCédric Chauvierre
Jun 14, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mieczysław Litwin, Anna Niemirska
May 26, 2012·Journal of Cardiovascular Disease Research·Troels ThimErling Falk
Apr 23, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ahmet TemizSabri Gazi
Aug 28, 2012·Advanced Drug Delivery Reviews·Marina G DamianoC Shad Thaxton
Apr 8, 2014·Stem Cells and Development·Na ZhangJian-An Wang
Apr 7, 2015·Journal of Avian Medicine and Surgery·Hugues BeaufrèreThomas N Tully
Sep 17, 2013·Journal of Women's Health·Janet M CatovRoberta B Ness
Mar 10, 2010·Journal of Biomedical Optics·Gijs van SoestAnton F W van der Steen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.