PMID: 2125670Oct 1, 1990Paper

Pathogenesis of bacterial respiratory infection and new approach of the treatment

Nihon Kyōbu Shikkan Gakkai zasshi
K Matsumoto

Abstract

Causative agents of respiratory infections has been changed because of increase in number of aged people and compromised host and the rapid development of new chemotherapeutic agents. Especially Branhamella catarrhalis (B. catarrhalis), which is very unique and has become a common respiratory pathogen, since 1980, in my department. Attachment ability of B. catarrhalis to oropharyngeal cells coincided with the acute exacerbation of chronic respiratory infections by this bacterium and the same phenomenon in pneumococcal infections was also established. In the hospital for aged people, two major pathogens Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) are specially seen. In these patients, the two major ones were isolated from the oropharynx. Non-typable Haemophilus influenzae (H. influenzae) is also very important in Japan like USA. Recurrent infection with this pathogen occurred due to the change of OMPs during the time period of more than one month. Complement and some amount of ceftadizim were inactivated by destroyed neutrophils in vitro. This result may explain one of the cause of intractability of P. aeruginosa infection. Monoclonal antibody against P. aeruginosa showed effectiveness in P. aeru...Continue Reading

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