PMID: 2511656Sep 1, 1989Paper

Pathogenesis of Brucella abortus infection of the mammary gland and supramammary lymph node of the goat

Veterinary Pathology
V P MeadorN F Cheville

Abstract

Goats, both in late pregnancy and soon after parturition, were inoculated intravenously with Brucella abortus, and mammary glands and supramammary lymph nodes were examined by light and electron microscopy at 2 to 55 days post-inoculation. After 7 days, lymphoplasmacytic, histiocytic interstitial mastitis with a lobular and periductal distribution were detected microscopically. Brucellae, identified in tissues with immunoperoxidase staining and antibody-coated colloidal gold stain, were first seen in macrophages and neutrophils throughout mammary parenchyma, but most commonly in mammary alveoli. In subsequent samples, infected phagocytes progressively increased in number, especially in ductal and alveolar lumina, and adjacent parenchyma. B. abortus was in phagosomes and phagolysosomes in macrophages and neutrophils; degenerate and necrotic phagocytes were often filled with brucellae. Extracellular brucellae were associated with ruptured necrotic infected phagocytes. Supramammary lymph nodes draining infected mammary glands were enlarged. Lymphofollicular hyperplasia, medullary plasmacytosis, and sinus histiocytosis were seen microscopically. Brucellae were seen exclusively in macrophages, which were most often located in subcap...Continue Reading

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Citations

Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Eman S RamadanHeba Hussien
Sep 1, 1989·Veterinary Pathology·V P MeadorN F Cheville
Feb 14, 2018·Journal of Clinical Microbiology·Noah HullBrant Schumaker
Nov 5, 1997·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D R EwaltP L Geer
Feb 13, 2021·Journal of Immunoassay & Immunochemistry·Polycarp TankoAjadi Abdullateef
Feb 13, 2021·Pathogens·Gabriela González-EspinozaJean-Pierre Gorvel
Feb 24, 2021·The Veterinary Quarterly·Maryam DadarKuldeep Dhama
Dec 25, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Tanguy MarcottyMarleen Boelaert
May 27, 2016·Microbiology Spectrum·Mariana X Byndloss, Renee M Tsolis
Oct 16, 2020·Microbiology and Molecular Biology Reviews : MMBR·Edgardo Moreno, Elías Barquero-Calvo
Sep 8, 2009·The Veterinary Journal·Alcina V Carvalho NetaRenato L Santos
Dec 4, 2009·Journal of Comparative Pathology·R González-BarrientosE Moreno

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