Pathogenesis of bullous pemphigoid

Immunology and Allergy Clinics of North America
Hideyuki UjiieHiroshi Shimizu

Abstract

Bullous pemphigoid, the most common autoimmune blistering disease, is induced by autoantibodies against type XVII collagen. Passive transfer of IgG or IgE antibodies against type XVII collagen into animals has revealed not only the pathogenicity of these antibodies but also the subsequent immune responses, including complement activation, mast cell degranulation, and infiltration of neutrophils and/or eosinophils. In vitro studies on ectodomain shedding of type XVII collagen have also provided basic knowledge on the development of bullous pemphigoid. The pathogenic role of autoreactive CD4+ T lymphocytes in the development of the pathogenic autoantibodies to type XVII collagen should also be noted.

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Citations

Jul 3, 2013·Experimental Dermatology·Mattias Collin, Marc Ehlers
Oct 6, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·D D OhD F Murrell
Nov 4, 2015·European Journal of Pharmacology·Roopesh Singh GangwarFrancesca Levi-Schaffer
Jun 19, 2015·Indian Journal of Dermatology, Venereology and Leprology·Yang MinChang Jian-Min
Jul 22, 2016·The American Journal of Dermatopathology·Markus BoosLeslie Castelo-Soccio
Jun 8, 2017·Clinical and Experimental Dermatology·T GambichlerS Hessam
Sep 21, 2017·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali Komi, Korneel Grauwet
Oct 23, 2019·Frontiers in Immunology·Kelly N MessinghamJanet A Fairley

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