Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B

Journal of the American Academy of Dermatology
Roger H Weenig

Abstract

The clinical syndrome of calciphylaxis is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, necrotic skin ulceration, and a high mortality rate. This review integrates calciphylaxis risk factors with the molecular processes governing osseous and extraosseous mineralization. As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow.

Associated Clinical Trials

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