PMID: 10679751Feb 19, 2000

Pathogenesis of cleft palate in mouse embryos exposed to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)

Teratogenesis, Carcinogenesis, and Mutagenesis
T N TakagiM Yasuda

Abstract

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cleft palate in mouse embryos. It has been believed that TCDD inhibits palatal fusion by suppression of disappearance of medial edge epithelial (MEE) cells on palatal shelves. However, we found that exencephalic mouse embryos were resistant to the cleft palate-inducing action of TCDD. In the present study, we examined cell kinetics in MEE and palatal mesenchyme in embryos exposed to TCDD with or without exencephaly for elucidation of pathogenesis of cleft palate by TCDD. Pregnant Jcl:ICR mice were given TCDD orally at 40 microg/kg at gestation day (GD) 12.5. Embryos were harvested between GD 13.5 and GD 14.5 and examined for cell kinetics by bromodeoxyuridine (BrdU) and TUNEL methods. Exencephaly was induced by intraperitoneal injection of CdCl(2) at 6 mg/kg at GD 7.5. BrdU-positive cells were decreased in TCDD-treated embryos in MEE and mesenchymal cells. TUNEL-positive cells were detected in MEE both in TCDD-treated and untreated control embryos, as well as in embryos with or without exencephaly. We also measured the gap between shelves between GD 14. 0 and GD 14.5. There were no differences at GD 14.0 between control and TCDD-exposed embryos, but at GD 14.25 and GD 14.5, TCD...Continue Reading

References

Apr 23, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Tomohiro YamadaTetsuya Yamamoto
Jul 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tracie R BakerWarren Heideman
May 12, 2007·The Review of Diabetic Studies : RDS·Keren MammonArkady Torchinsky
Dec 18, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Terry C HrubecSteven D Holladay
May 11, 2004·The Journal of Veterinary Medical Science·Satoshi FurukawaIzumi Ogawa
Sep 24, 2004·Journal of Dental Research·Y SasakiY Taya
Jun 17, 2005·Human & Experimental Toxicology·Chada S Reddy
Mar 8, 2005·Archives of Environmental Contamination and Toxicology·M KobayashiK Mitsumori
Jul 19, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Caren M Villano, Lori A White
Aug 2, 2003·Congenital Anomalies·Hiroki TeraokaTakeo Hiraga
Jun 11, 2016·Experimental and Therapeutic Medicine·Liyun GaoWeidong Wu
Nov 28, 2018·Dose-response : a Publication of International Hormesis Society·Gao LiyunJia Cao
Mar 12, 2019·Dose-response : a Publication of International Hormesis Society·Liyun GaoJia Cao
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Daniel J KimAkiko Iwasaki
Feb 3, 2019·International Journal of Molecular Sciences·Wataru Yoshioka, Chiharu Tohyama

Citations

Nov 1, 1976·Developmental Biology·R M Pratt, R M Greene
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Feb 1, 1989·Developmental Biology·J E Fitchett, E D Hay
Jun 15, 1989·Toxicology and Applied Pharmacology·B D Abbott, L S Birnbaum
Jun 15, 1989·Toxicology and Applied Pharmacology·B D Abbott, L S Birnbaum
Aug 1, 1989·Toxicology and Applied Pharmacology·B D AbbottL S Birnbaum
Nov 1, 1971·Toxicology and Applied Pharmacology·K D Courtney, J A Moore
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·R M PrattV M Diewert

Related Concepts

Embryo
Pathogenic Aspects
Pathogenesis
Structure of Papilla Incisiva of Mouth
Iniencephaly
Tetrachlorodibenzodioxin
Cleft Palate, Isolated
Cadmium chloride
Gestational Age
Visual Suppression

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