Pathogenesis of early atherosclerotic lesions in infants

Pathology, Research and Practice
Luigi MatturriAnna Maria Lavezzi

Abstract

High serologic lipid levels, infections, and genetic susceptibility have been proposed as possible etiologic factors of initial atherosclerotic lesions of the coronary arteries in infancy. At a recent WHO annual meeting, it was stated that breast milk substitutes cause irreparable damage in infants. This prompted us to verify whether formula feeding and parental cigarette smoking might play a role in the pathogenesis of early atherosclerotic alterations in infancy. The major epicardial coronary arteries from 36 infants dying suddenly and unexpectedly (sudden infant death syndrome) were embedded in paraffin and serially cut for histologic examination. In 67% of the cases, multifocal coronary early atherosclerotic lesions of varying entities were detected. The alterations ranged from focal plaques with mild myointimal thickening to juvenile soft plaques reducing the arterial lumen. A significant correlation was observed between the early atherosclerotic lesions and the risk factors considered. In particular, we noted different morphologic patterns related to formula feeding and cigarette smoking. Baby formula feeding and parental cigarette smoking might have an atherogenic effect on the coronary walls as from the first months of ...Continue Reading

Citations

Jan 18, 2007·Maternal and Child Health Journal·Jose G Dorea
Jun 11, 2005·Virchows Archiv : an International Journal of Pathology·Luigi MatturriAnna Maria Lavezzi
Feb 23, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anna Maria LavezziLuigi Matturri
Sep 11, 2004·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Luigi MatturriLino Rossi
Sep 13, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Giulia Ottaviani, L Maximilian Buja
Nov 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Caroline C GeertsCuno S P M Uiterwaal
May 21, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Nour A Al-SawalhaOmar F Khabour
Jul 3, 2009·The Open Cardiovascular Medicine Journal·D MecchiaL Matturri

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