Pathogenesis of focal glomerulosclerosis

Nephron
W K Bolton, E Abdel-Rahman

Abstract

Focal segmental glomerulosclerosis (FSGS) is the histologic expression of diverse processes affecting the renal glomeruli and occurring in primary and secondary forms. A number of pathogenic factors have been identified in primary FSGS, and multiple etiologies have been defined as contributing factors for the development of secondary FSGS. There is a complex interplay between etiologic and pathogenic factors, progression factors and intervention in the phenotypic expression of FSGS. Key components include genetic predisposition, environmental influences and the impact on phenotype of pharmacologic intervention. The phenotypic spectrum for FSGS ranges from mild proteinuria and slow progression to a devastating clinical syndrome characterized by heavy proteinuria and rapid loss of renal function over a period of months. While the pathogenesis is unknown, much is known about factors which are involved in the development and progression of both primary and secondary FSGS. The ultimate goal of understanding pathogenesis is to provide specific nontoxic therapy for those patients who have a definable form of FSGS. While this goal is not yet in sight, many types of intervention, not addressed in the current chapter, can influence the c...Continue Reading

Citations

Sep 5, 2002·Journal of Clinical Anesthesia·Bhiken NaikVikas R Dharnidharka
Feb 23, 2013·ISRN Hematology·Ronit Vogt Sionov
Jul 11, 2006·The American Journal of Medicine·J Gabe SchneiderPatrick R Sosnay
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Robyn Cunard, Carolyn J Kelly
Jul 17, 2004·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Marina AunapuuMai Ots

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