Pathogenesis of Graves' orbitopathy: a 2010 update.

Journal of Endocrinological Investigation
Terry J Smith

Abstract

The most important of the extra-thyroidal manifestations of Graves' disease, Graves' orbitopathy (GO), remains a vexing clinical problem. Treatment of severe active disease has been limited to steroids or radiotherapy. In the relatively rare case where vision is threatened, emergent decompression surgery can be performed. The proptosis, motility, or cosmetic concerns associated with stable GO are commonly remedied with surgical intervention. Substantial obstacles have prevented the development of specific medical therapies for GO, in large part resulting from poor understanding of disease pathogenesis and the absence of preclinical animal models. Fundamental aspects of GO's etiology have been uncovered from studies based in cell culture, extensive analysis of blood constituents, and detailed examination of orbital contents collected at the time of surgical intervention. Many of the published reports resulting from these studies are descriptive and all have failed to yield unifying concepts that integrate the anatomically divergent manifestations of Graves' disease. This brief review covers recent findings of several research groups. While major breakthroughs continue to occur in closely related autoimmune diseases, progress in ...Continue Reading

References

Nov 3, 1975·Biochemical and Biophysical Research Communications·B ArbogastA Dorfman
Jun 25, 1992·The New England Journal of Medicine·L TallstedtA Taube
Dec 22, 1989·Science·M ParmentierG Vassart
Jan 1, 1968·Physiological Reviews·J M McKenzie
Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·A E HeufelderR S Bahn
Jan 1, 1993·Autoimmunity·D R WeightmanP Kendall-Taylor
May 5, 1995·The Journal of Biological Chemistry·T EndoT Onaya
Feb 15, 1993·Biochemical and Biophysical Research Communications·T EndoT Onaya
Sep 1, 1996·The Journal of Clinical Endocrinology and Metabolism·A SoriskyT J Smith
Jan 8, 1998·The New England Journal of Medicine·L BartalenaA Pinchera
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·R W ValyaseviR S Bahn
Jul 20, 1999·Thyroid : Official Journal of the American Thyroid Association·K HaraguchiT Onaya
Jul 27, 2000·American Journal of Physiology. Cell Physiology·A BellA Sorisky
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane PritchardTerry J Smith
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Terry J SmithAlexander Sorisky
Jan 29, 2002·European Journal of Immunology·Laura KoumasRichard P Phipps
Mar 26, 2002·Nature Reviews. Immunology·Carol L Vanderlugt, Stephen D Miller
Oct 3, 2002·Annual Review of Medicine·Raphaela Goldbach-Mansky, Peter E Lipsky
Nov 30, 2002·European Journal of Endocrinology·Patrizia AgrettiMassimo Tonacchera
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane PritchardTerry J Smith
Dec 13, 2003·Endocrine Reviews·Bellur S PrabhakarTerry J Smith
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Timothy E QuanRichard Bucala
May 29, 2004·Journal of Endocrinological Investigation·T MizokamiJ R Wall
Jun 14, 2006·International Ophthalmology Clinics·Mitesh K Kapadia, Peter A D Rubin
Aug 8, 2006·Thyroid : Official Journal of the American Thyroid Association·Daniel El FassiLaszlo Hegedüs
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Daniel El FassiLaszlo Hegedüs
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raymond S DouglasTerry J Smith
May 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Terry J Smith
Sep 25, 2007·Thyroid : Official Journal of the American Thyroid Association·Bamini GopinathJack R Wall
Jul 17, 2008·European Journal of Endocrinology·Karen A HeemstraJohannes W Smit
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanli TsuiTerry J Smith
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raymond S DouglasTerry J Smith
Oct 31, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniel El FassiClaus H Nielsen
Jun 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Hadas Stiebel-KalishLeonard Leibovici
Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·G VannucchiM Salvi
Jul 8, 2009·Nature Reviews. Rheumatology·Thomas DörnerGerd R Burmester
Jul 31, 2009·The Journal of Investigative Dermatology·Francesca CianfaraniMassimino D'Armiento

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Citations

Jun 11, 2014·Journal of Endocrinological Investigation·Luigi Bartalena, Vahab Fatourechi
Dec 17, 2011·Journal of Thyroid Research·Miloš Zarković
Feb 9, 2012·Journal of Thyroid Research·Leonidas H Duntas
May 12, 2012·Journal of Thyroid Research·C KamathL D Premawardhana
Jan 26, 2012·Endocrine·Maria Laura TandaLuigi Bartalena
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Chiaw-Ling ChngDaphne Hsu Chin Khoo
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Luigi Bartalena
Aug 9, 2011·Otolaryngologic Clinics of North America·Dan RobinsonRaymond Sacks
Feb 24, 2016·Expert Review of Clinical Pharmacology·Poupak FallahiAlessandro Antonelli
Mar 13, 2014·Clinical & Experimental Ophthalmology·Guohong GaoFei Ma
Mar 6, 2015·Journal of Endocrinological Investigation·F MenconiM Marinò
Jul 30, 2015·International Journal of Endocrinology·Miaoli LinDan Liang
Aug 11, 2017·The British Journal of Ophthalmology·Ana Beatriz Diniz GrisoliaCésar Augusto Briceño
Oct 28, 2011·Thyroid : Official Journal of the American Thyroid Association·Hanna Wichary, Teresa Gasińska
Oct 18, 2012·Thyroid : Official Journal of the American Thyroid Association·Roberto RocchiStefano Sellari-Franceschini
Jul 13, 2012·Thyroid : Official Journal of the American Thyroid Association·Susanne NeumannMarvin C Gershengorn
Sep 15, 2018·Endocrine Reviews·Terry J Smith, Joseph A M J L Janssen
Oct 6, 2012·The Journal of Clinical Endocrinology and Metabolism·L BartalenaUNKNOWN European Group on Graves' Orbitopathy
Jul 16, 2014·Ophthalmic Plastic and Reconstructive Surgery·Luigi Bartalena
Jan 11, 2020·International Ophthalmology·Jessica M Pouso-DizFrancisco Gonzalez
Apr 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Yan GuoYanbing Li
Nov 12, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hong LiYucheng Yang
Apr 20, 2018·Journal of Immunology Research·Alice BruscoliniAlessandro Lambiase
Aug 12, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Mario Salvi
Dec 31, 2010·The Journal of Clinical Endocrinology and Metabolism·Luigi Bartalena
Aug 17, 2020·AJNR. American Journal of Neuroradiology·C FeeneyS Nagendran
Dec 29, 2020·The Journal of Clinical Endocrinology and Metabolism·Alessandro AntonelliPoupak Fallahi
Mar 31, 2021·Hormones : International Journal of Endocrinology and Metabolism·Jing ChenHuilan Sun
Apr 15, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Yizhi DingHua Gao
Jun 22, 2021·Frontiers in Endocrinology·Terry J Smith

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