PMID: 11335138May 4, 2001Paper

Pathogenesis of herpes simplex virus type 2 experimental genital infection in pregnant mice

FEMS Immunology and Medical Microbiology
N A Sanjuan, M N Zimberlin

Abstract

The progression of herpes simplex-2 genital infection in pregnant mice was studied by detection of viral antigens using immunoperoxidase in tissue sections, electron microscopy and virus isolation. The majority of mice (66.66%) died at 8-9 days post-inoculation. Abortions were observed in 69.23% of the infected mice along with impairment of labor and delivery. Herpes antigens were detected in most of the autonomic nerves of the uterus, including those surrounding small arterioles in the myometrium and the Auerbach and Meissner plexa of the large bowel, but not in the abortions or placentas. The infection of uterine autonomic fibers and myometrial cells could explain the delivery impairment and could have provoked a decrease in blood flow leading to abortions.

References

Mar 1, 1975·Infection and Immunity·J C OverallL A Glasgow
Sep 1, 1992·International Journal of STD & AIDS·R N Shen, R N Thin
Dec 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C G ProberA M Arvin
Oct 1, 1985·American Journal of Obstetrics and Gynecology·K YamadaM Suzuki
Nov 12, 1987·The New England Journal of Medicine·Z A BrownL Corey
Jan 1, 1988·Journal of Perinatal Medicine·M BujkoI Bardic
Jan 1, 1980·Archives of Virology·E F Lascano, M I Berria
Apr 1, 1983·American Journal of Obstetrics and Gynecology·J H HargerM Ho
Jan 1, 1982·Journal of Neural Transmission·M MoscariniF Amenta
Aug 21, 1997·The New England Journal of Medicine·Z A BrownL Corey
Aug 1, 1997·International Journal of Epidemiology·R BrughaA Meheus
Mar 28, 1998·Gynecologic and Obstetric Investigation·S SifakisD A Spandidos

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Citations

Mar 1, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·María Inés Gonzalez, Norberto A Sanjuan
Jan 4, 2006·International Journal of Immunopathology and Pharmacology·M I GonzalezG A Rabinovich
Dec 17, 2010·Journal of Virology·Masahiro OhashiPhilip R Krause
Aug 4, 2016·Journal of Cellular Biochemistry·Gláubia SartoriCristina W Nogueira

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