Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

Frontiers in Cellular and Infection Microbiology
Lu JiaYi Liu

Abstract

Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases. Recently, the regulation between host immunologic response and periodontal pathogens has become a hotspot to explain the mechanism of periodontitis and related systemic diseases. Since Porphyromonas gingivalis (P. gingivalis) was proved as critical periodontal pathogen above all, researches focusing on the mechanism of its virulence factors have received extensive attention. Studies have shown that in the development of periodontitis, in addition to the direct release of virulent factors by periodontal pathogens to destroy periodontal tissues, over-low or over-high intrinsic immune and inflammatory response mediated by Toll-like receptors (TLRs) can lead to more lasting destruction of periodontal tissues. It is very necessary to sort out how various cytopathic factors of P. gingivalis mediate inflammation and immune responses between the host through TLRs so as to help precisely prevent, diagnose, and treat periodontitis in clinic. This review summarizes the role of three most widely studied pathogenic factors produced by P. gingivalis (lipopolysaccharide, gingipains, pili) and their interactions with TLRs at the cellular and molecula...Continue Reading

References

Mar 23, 2000·European Journal of Biochemistry·A B SchrommU Seydel
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A VisintinD M Segal
Dec 19, 2001·Infection and Immunity·Hakimuddin T SojarRobert J Genco
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P-L Wang, K Ohura
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Apr 27, 2005·Nature Immunology·Senad DivanovicChristopher L Karp
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshinori NagaiKensuke Miyake
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen R CoatsRichard P Darveau
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Jul 25, 2006·Journal of Dental Research·E NemotoM J Somerman
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min WangGeorge Hajishengallis
Nov 6, 2007·Journal of Clinical Microbiology·Morten EnersenDominique A Caugant
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·George HajishengallisKathy Triantafilou
Jul 25, 2009·Oral Diseases·N B ParahitiyawaL P Samaranayake
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elia BurnsGabriel Nussbaum
Feb 18, 2010·Science Signaling·Min WangGeorge Hajishengallis
Aug 20, 2010·Nature Immunology·Daniel RicklinJohn D Lambris
Nov 3, 2010·FEMS Immunology and Medical Microbiology·Rieko ItoKatsuji Okuda
Nov 26, 2010·Dental Clinics of North America·Dana L Wolf, Ira B Lamster
Jun 11, 2011·Advances in Experimental Medicine and Biology·Tang YongqingLakshmi C Wijeyewickrema
Apr 26, 2012·FEMS Microbiology Letters·Nagihan Bostanci, Georgios N Belibasakis
Dec 21, 2012·Journal of Cellular Physiology·Kenneth BarthCaroline A Genco
Dec 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stacy L KelleyRichard I Tapping
Dec 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·George PapadopoulosCaroline A Genco
Jan 3, 2013·Molecular Oral Microbiology·A W AruniH M Fletcher

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Citations

Aug 8, 2020·Frontiers in Immunology·Keisuke YamashiroShogo Takashiba
Apr 9, 2020·Critical Reviews in Microbiology·Aditi ChopraMohit Sharma
May 1, 2021·Cancers·Se-Young ParkNa-Young Song
May 11, 2021·Frontiers in Microbiology·Alex KnowlesPrachi Stafford
Feb 20, 2021·Canadian Journal of Microbiology·Celine Stoica, Georgina Cox
May 28, 2021·European Journal of Dentistry·Theresia Indah BudhyAnisa Nur Halimah
Aug 28, 2021·International Journal of Molecular Sciences·Peiya LinSayaka Katagiri
Oct 10, 2021·Clinical and Experimental Dental Research·Thuraya ElgreuXiaoren Tang

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Methods Mentioned

BETA
acylation
acetylation

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