Pathogenesis of innate immunity and adaptive immunity in the mouse model of experimental autoimmune uveitis

Journal of the Chinese Medical Association : JCMA
Hong-Sheng BiYan Cui

Abstract

Experimental autoimmune uveitis, a well-established model for human uveitis, is similar to human uveitis in many pathological features. Studies concerning the mechanisms of experimental autoimmune uveitis would cast a light on the pathogenesis of human uveitis as well as the search for more effective therapeutic agents. The cellular components of innate immunity include natural killer cells, gamma delta T lymphocytes, antigen-presenting dendritic cells, phagocytic macrophages, and granulocytes. It is believed that T cells are central in the generation of human uveitis. It has already become clear that CD4(+) effecter cells that predominantly produce interleukin-17 (the so-called Th17 cells) may play an important role in uveitis. In addition, the occurrence and recurrence of uveitis depends on a complex interplay between the elements of innate and adaptive immunity.

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Citations

Mar 13, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Arnaud SauerClaude Speeg-Schatz
Jun 2, 2016·Ocular Immunology and Inflammation·Denis WakefieldPeter McCluskey
Nov 30, 2016·World Journal of Gastroenterology : WJG·Carla Melisa ChackeleviciusNatalia Rosso
Dec 15, 2018·Journal of Cellular and Molecular Medicine·Qiang FuWei Lin

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