PMID: 9446005Jan 31, 1998Paper

Pathogenesis of interstitial kidney fibrosis. Studies in the rat model of unilateral ureteral obstruction

Medizinische Klinik
M Sommer, R Fünfstück

Abstract

The animal model of unilateral ureteral obstruction (UUO) of the rat is suitable to cause a renal interstitial fibrosis within a few weeks. Prior to the 10th day after UUO, no fibrotic changes were detectable in ureter-ligated kidneys, whereas after day 20 fibrosis was developing strongly. Using cell cultures it was examined whether any in vivo changes in proliferation and function of fibroblasts are also detectable in cell cultures and whether, due to their persistency, they are of fundamental importance for the development of renal interstitial fibrosis. The comparison of the proliferation in cell cultures established 5 and 21 days after UUO showed that the cultures of the two experimental groups behave similarly. Consequently, the action of acute inflammatory processes on fibroblast proliferation without any existing fibrosis is comparable with that of pronounced fibrosis in the animal model. High concentrations of fetal calf serum in the culture medium cause a stimulation of the cell proliferation as well as a selection of mitotically active differentiation stages of fibroblasts. Obviously, the loss of inhibition of the fibroblast proliferation under the conditions of cell culture causes similar changes to those effected by...Continue Reading

References

Mar 1, 1991·Kidney International·G Wolf, E G Neilson
Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H P Rodemann, G A Müller
Mar 1, 1991·Kidney International·G S KuncioT Haverty
Oct 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·H P Rodemann, G A Müller
Jun 23, 1988·The New England Journal of Medicine·S KlahrI Ichikawa
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