Pathogenesis of middle ear adhesions

The Laryngoscope
P Cayé-ThomasenK Prellner

Abstract

Middle ear adhesions are well-known to the ear surgeon, although data on etiology, pathogenesis, and significance are lacking in current literature. This study on experimental acute otitis media presents histopathological data on these aspects. Pneumococci were inoculated in the right middle ear bulla of 25 rats; the left ear served as control. At days 4, 8, 16, 90, and 180, respectively, 5 rats were decapitated, and the bullae were removed, opened, and stained with periodic acid-Schiff (PAS)/alcian blue. The entire middle ear mucosae were dissected from the bone, embedded as whole mounts in colophonium chambers, and examined by light microscopy. Representative parts of the mucosae were sectioned and examined in the same way. All inoculated ears from day 8 and later (20 in total), contained mucosal adhesions of various sizes, shapes, and locations. None were found in control ears. The site of predilection for the development of adhesions was the hypotympanum, followed by the anterior epitympanum, the attic, the drum, the interossicular spaces, and the tubal orifice. Based on present histopathological findings, we conclude that the middle ear adhesion is a pathological phenomenon caused by infection, and we propose a six-stage h...Continue Reading

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Citations

Mar 14, 2013·Journal of the Association for Research in Otolaryngology : JARO·Xiying Guan, Rong Z Gan
Aug 8, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Xiying GuanRong Z Gan
Sep 28, 2006·Allergy·J-B WateletUNKNOWN GA(2)LEN Workpackage Members 2.7
Sep 28, 1998·The Annals of Otology, Rhinology, and Laryngology·P Cayé-Thomasen, M Tos
Apr 24, 2002·The Annals of Otology, Rhinology & Laryngology. Supplement·Cuneyt M AlperTomonori Takasaka
Mar 23, 2019·Disease Models & Mechanisms·Jorge Del-PozoMichael Cheeseman

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