Pathogenesis of migration disorders

Current Opinion in Neurology
Pierre Gressens

Abstract

Neocortical neurons have to migrate from their site of production in the periventricular germinative zone or in the ganglionic eminence towards the cortical plate. Our understanding of the underlying molecular mechanisms has advanced considerably in recent years due to the identification of genes involved in human migration disorders and experimental studies. This review will highlight some of the most recent findings in the deciphering of the molecular machinery controlling neuronal migration. Neuronal migration is a complex process which involves cytoskeletal molecules controlling the initiation of migration, leading edge extension and nucleokinesis; signalling molecules (the reelin pathway playing a central role) integrating external signals and linking them to the cytoskeleton; stop signals; and other molecular players including neurotrophins, glutamate receptors and peroxisome-derived factors. Emerging evidence supports the existence of cross-talk between these pathways. Identifying these mechanisms has shed light on typical human neuronal migration disorders such as periventricular heterotopias (disorder of migration initiation linked to filamin), type I lissencephaly (cytoskeletal abnormality linked to Lis1, a microtubul...Continue Reading

References

Jun 8, 1992·Neuroscience Letters·P GressensP Evrard
Oct 11, 1991·Science·S K McConnell, C E Kaznowski
Nov 1, 1993·Journal of Neuropathology and Experimental Neurology·G LyonE Della Giustina
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·S MarretP Evrard
Sep 1, 1997·Nature Genetics·M BaesG P Mannaerts
Jun 17, 2000·Results and Problems in Cell Differentiation·J E Brunstrom, A L Pearlman
Dec 5, 2000·Pediatric Research·P Gressens
Feb 7, 2004·The EMBO Journal·Amos GdalyahuOrly Reiner
Jun 29, 2004·Trends in Neurosciences·Arnold R Kriegstein, Stephen C Noctor
Aug 28, 2004·The American Journal of Pathology·Matthew F McManusJeffrey A Golden
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tobias WillerJesús Cruces
Oct 7, 2004·Brain Research. Developmental Brain Research·Juan Ramon Martinez-GalanAntonio Ruiz-Marcos
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Stephanie BielasJoseph G Gleeson
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takashi NaganoMakoto Sato
Dec 14, 2004·Cerebral Cortex·Christian González-BillaultJesús Avila
Dec 21, 2004·Molecular and Cellular Neurosciences·Gaëlle FriocourtJamel Chelly
Jan 6, 2005·The Journal of Biological Chemistry·Miki TsukadaGregor Eichele
Mar 15, 2005·The Biochemical Journal·Eva M Jiménez-MateosChristian González-Billault
May 11, 2005·Neuron·Li-Huei Tsai, Joseph G Gleeson
May 24, 2005·Neuromuscular Disorders : NMD·Tomohiro ChiyonobuTatsushi Toda
May 27, 2005·Current Opinion in Genetics & Development·Stephen P Robertson
Sep 8, 2005·The Journal of Cell Biology·Jin-Wu TsaiRichard B Vallee
Sep 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ying ChenJoachim Herz
Sep 15, 2005·The Journal of Cell Biology·Mary E Hatten
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bruce T Schaar, Susan K McConnell
Jun 1, 1998·Annals of the New York Academy of Sciences·Michael S Lidow

❮ Previous
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Citations

Jun 24, 2009·The Cerebellum·Donald Bryant CameronHitoshi Komuro
Oct 20, 2010·The Journal of Biological Chemistry·Toshifumi FukudaShigeru Yanagi
Nov 26, 2009·Brain : a Journal of Neurology·A James BarkovichWilliam B Dobyns
Sep 15, 2009·Journal of Veterinary Internal Medicine·M M BrosnahanJ W Ritchey
Sep 29, 2011·Rinshō shinkeigaku = Clinical neurology·Hiroshi Shigeto
Jan 27, 2012·Rinshō shinkeigaku = Clinical neurology·Hiroshi Shigeto
Jun 14, 2013·Epilepsy Research and Treatment·Joe Yuezhou Yu, Phillip L Pearl
Feb 2, 2013·Der Radiologe·I PogledicW Reith
Jul 29, 2009·Neuropharmacology·M Hava GolanJ Regino Perez-Polo
Mar 7, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Alberto VerrottiPaola Iannetti
Sep 13, 2008·Molecular and Cellular Neurosciences·Carmen Díaz-RuizEduardo Soriano
Jun 16, 2007·Revue neurologique·A VerloesP Gressens
Mar 6, 2007·Seminars in Fetal & Neonatal Medicine·Gunilla Malm, Mona-Lisa Engman
May 21, 2009·The European Journal of Neuroscience·Shymaa E BilasyTohru Kataoka
Mar 28, 2008·Aging Cell·Anton PekcecHeidrun Potschka
Jan 6, 2009·Acta Paediatrica·Alberto SpalicePaola Iannetti
Jul 18, 2015·Neurobiology of Disease·Xiangning Jiang, Jeannette Nardelli
Sep 30, 2006·Biochimica Et Biophysica Acta·Myriam Baes, Paul P Van Veldhoven
Nov 9, 2007·Neuron·Adam V KwiatkowskiFrank B Gertler
Mar 13, 2012·Journal of Child Neurology·Attila MokánszkiEva Oláh
Jul 13, 2011·Veterinary Pathology·P VogelB P Zambrowicz
May 31, 2018·Der Radiologe·I Pogledic
Nov 20, 2018·Antiviral Chemistry & Chemotherapy·Ashwaq A AbdullahMohd-Azmi Mohd-Lila
Dec 28, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ming-Wei ChaoChia-Yi Tseng
Sep 15, 2018·Communicative & Integrative Biology·Ulrike TheisenReinhard W Köster
Mar 25, 2019·NeuroImage·Lana VasungEmi Takahashi

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