PMID: 6539250Jun 1, 1984Paper

Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper

Experimental and Molecular Pathology
J M GutiérrezG V Odell

Abstract

The pathogenesis of skeletal muscle necrosis induced by crude Bothrops asper venom and isolated myotoxic phospholipase was studied using light and electron microscopy. White mice were injected intramuscularly with a dose of 2.5 micrograms/g and tissue samples were taken at 30 min and 1, 3, 6, 12, 24, and 48 hr. Toxin-injected muscle showed localized wedge-shaped lesions ("delta lesions") by 30 min, which included disrupted plasma membranes. At 1 and 3 hr the predominant type of necrotic cell contained clumped myofibrils in which individual myofilaments were indistinguishable. At later time periods there was a relaxation and redistribution of myofilaments resulting in a more homogeneous and hyaline appearance of necrotic cells. Some mitochondria were swollen and had flocculent densities, and most of them were disrupted, having only one membrane and vesiculated cristae. The basal lamina was intact at all time intervals. Phagocytosis of muscle cell debris started at 3 hr and was prominent by 24-48 hr. In crude venom-injected muscle many cells showed pathologic features identical to those observed after myotoxin injection. Crude venom also induced hemorrhage which was evident 30 min after injection, reaching its highest level by 12...Continue Reading

Citations

Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezG V Odell
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·B LomonteE Mata
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezL Cerdas
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·D Mebs
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezL Cerdas
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·D Mebs, Y Samejima
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezL Cerdas
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezL Cerdas
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·F BrenesB Lomonte
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·E Moreno, J M Gutiérrez
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·F ChavesL Cerdas
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·B Lomonte, J M Gutiérrez
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezK Schosinsky
Feb 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·E BultrónM Thelestam
May 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·L C MancusoJ R Giglio
Nov 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·J M Gutiérrez, B Lomonte
Jan 1, 1990·Pharmacology & Therapeutics·D Mebs, C L Ownby
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·O ArroyoL Cerdas
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J M GutiérrezL Cerdas
Jan 1, 1990·Electron Microscopy Reviews·J B Harris, M J Cullen
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·José María Gutiérrez, Charlotte L Ownby
Apr 18, 2001·Toxicon : Official Journal of the International Society on Toxinology·M ChacurY Cury
Aug 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·S R ZamunerC F Teixeira
Jun 22, 2002·Toxicon : Official Journal of the International Society on Toxinology·M ChacurY Cury
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Fernando ChavesJosé María Gutiérrez
Aug 9, 2003·Toxicon : Official Journal of the International Society on Toxinology·Vera L Petricevich, Ronaldo Z Mendonça
Jun 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·G BorkowM Ovadia
Jun 10, 1998·Toxicon : Official Journal of the International Society on Toxinology·G LeónJ M Gutiérrez
Oct 29, 1998·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezF Chaves
Jan 27, 1999·Toxicon : Official Journal of the International Society on Toxinology·B LomonteJ M Gutiérrez
Sep 1, 1990·Baillière's Clinical Endocrinology and Metabolism·J B Harris, P G Blain
Jun 26, 2001·International Journal of Experimental Pathology·M Lopes-FerreiraJ M Gutiérrez
Mar 1, 2012·PLoS Neglected Tropical Diseases·Irene ZornettaCesare Montecucco
Nov 13, 2012·Phytochemistry·M M MendesV M Rodrigues
Oct 3, 2012·Toxicon : Official Journal of the International Society on Toxinology·José María Gutiérrez, Bruno Lomonte
Aug 26, 2009·Toxicon : Official Journal of the International Society on Toxinology·Neide Galvão NascimentoCatarina Teixeira
Dec 1, 2015·Toxicon : Official Journal of the International Society on Toxinology·José María Gutiérrez
Mar 24, 2009·Toxicon : Official Journal of the International Society on Toxinology·José María GutiérrezTeresa Escalante
Oct 5, 2007·Toxicon : Official Journal of the International Society on Toxinology·José María GutiérrezBruno Lomonte
Jan 6, 2007·Toxicon : Official Journal of the International Society on Toxinology·Renata do A OlivoStella R Zamuner
Feb 3, 2005·Toxicon : Official Journal of the International Society on Toxinology·Juliana P ZulianiCatarina F P Teixeira

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