Pathogenesis of nonsteroidal antiinflammatory drug-induced asthma

Current Opinion in Allergy and Clinical Immunology
Seung-Hyun Kim, Hae-Sim Park

Abstract

To summarize recent findings related to the pathogenic mechanisms of aspirin-induced asthma with emphasis on molecular genetic mechanisms. The overproduction of cysteinyl leukotrienes with the increased expression of cysteinyl leukotriene receptor 1 (CYSLTR1) is a consistent finding in aspirin-induced asthma patients. Recent data have suggested a dysregulation of cyclooxygenase-2 and prostaglandin E2, increased levels of 15-hydroxyeicosatetranoic acid, and decreased lipoxin generation as characteristics of the condition. The HLA allele DPB10301 was documented as a strong genetic marker for susceptibility in an Asian population. Leukotriene C4 synthase has been established as a key genetic determinant of aspirin-induced asthma, but recent studies have demonstrated that several single nucleotide polymorphisms in the promoters of prostaglandin E2 receptor subtype 2, CYSLTR1 and CYSLTR2 and T-box expressed in T cells (TBX21) could increase risk for the condition. Although cyclooxygenase-2 and thromboxane A2 receptor polymorphisms were not associated with aspirin-induced asthma phenotype, they may exert functional effects. The identification of genetic markers for aspirin-induced asthma susceptibility along with in-vitro functional ...Continue Reading

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Citations

May 15, 2007·Pharmacogenetics and Genomics·Sang-Heon KimKyung-Up Min
Jan 1, 2010·Journal of Asthma and Allergy·Anne-Marie Madore, Catherine Laprise
Nov 21, 2008·Respiratory Medicine·Sang-Heon KimHae-Sim Park
Nov 30, 2006·Current Opinion in Pulmonary Medicine·James KileyPatricia Noel
Jul 11, 2006·Current Opinion in Allergy and Clinical Immunology·Seung-Hyun KimHae-Sim Park
Jan 24, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Ehsan Baghani, Aviv Ouanounou
Jul 11, 2006·Current Opinion in Allergy and Clinical Immunology

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