Abstract
Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N8 strains did not induce mortality and significant respiratory signs after an intranasal challenge in ferrets. However, ferrets intratracheally infected with A/broiler duck/Korea/Buan2/2014 virus showed dose-dependent mortality. Although the Korean H5N8 strains were classified as the HPAI virus, possessing multiple basic amino acids in the cleavage site of the hemagglutinin sequence, they did not produce pathogenesis in ferrets challenged intranasally, similar to the natural infection route. These results could be useful for public health by providing the pathogenic characterization of H5N8 viruses.
References
Apr 1, 1989·Journal of Virological Methods·P D ReumanG M Schiff
Aug 10, 2000·Revue Scientifique Et Technique·D E Swayne, D L Suarez
Oct 1, 2004·Lab Animal·John A Maher, Joanne DeStefano
Sep 6, 2005·Journal of Virology·Taronna R MainesTerrence M Tumpey
Mar 15, 2006·The Journal of Experimental Medicine·Rachelle SalomonErich Hoffmann
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Aug 10, 2007·Journal of Virology·Jessica A BelserTerrence M Tumpey
Jun 3, 2010·Virology Journal·Yong-Gang LiPathom Sawanpanyalert
Jun 11, 2010·Journal of Virology·Yuan FangDavid J Kelvin
Jun 7, 2011·The American Journal of Pathology·Rogier BodewesThijs Kuiken
Dec 14, 2011·The Journal of Infectious Diseases·Taronna R MainesTerrence M Tumpey
Jun 23, 2012·Science·Sander HerfstRon A M Fouchier
Feb 5, 2013·Veterinary Microbiology·Kunkun ZhaoXiufan Liu
Jul 3, 2013·Vaccine·J H C M KreijtzA D M E Osterhaus
Mar 25, 2014·Virus Research·Donghyok KwonChun Kang
May 27, 2014·Emerging Infectious Diseases·Youn-Jeong LeeHee-Soo Lee
Aug 29, 2014·Veterinary Research·Beatriz VidañaNatàlia Majó
Jan 28, 2015·Emerging Infectious Diseases·Hyun-Mi KangYoun-Jeong Lee
Jun 4, 2015·Emerging Microbes & Infections·Young-Il KimYoung Ki Choi
Citations
Mar 19, 2016·Scientific Reports·Yohannes BerhaneJohn Pasick
Sep 30, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Marjolein J PoenRon A M Fouchier
Apr 11, 2017·Scientific Reports·Yue DingWei Xiao
Aug 1, 2015·Journal of Virology·Joanna A Pulit-PenalozaTerrence M Tumpey
Jul 21, 2020·Emerging Microbes & Infections·Yanfang CuiHualan Chen
Oct 7, 2018·Archives of Virology·Mi-Seon LeeHwajung Yi
Jul 22, 2018·Emerging Microbes & Infections·Christian GrundMartin Beer
Jan 10, 2020·PloS One·Eun-Ji ChoiMyung Guk Han
Jul 29, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Haibo WuNanping Wu