Pathogenesis of O157:H7 Escherichia coli infection in neonatal calves

Advances in Experimental Medicine and Biology
Evelyn A Dean-NystromH W Moon

Abstract

Cattle have been implicated as an important reservoir of Shiga-like toxin-producing Escherichia coli (SLTEC) O157:H7, enterohemorrhagic E. coli (EHEC) that cause hemorrhagic colitis and hemorrhagic uremic syndrome in humans. Naturally- or experimentally-infected cattle can shed low levels of E. coli O157:H7 long-term, but little is known about the pathogenesis of E. coli O157:H7 infection in cattle. E. coli O157:H7 induce characteristic attaching and effacing (A/E) mucosal lesions in ceca and colons of 1-day-old gnotobiotic piglets and this model is used to study the pathogenesis of SLTEC infections. A/E lesions were not detected in histologic sections of the intestines from adult cattle or 3- to 14-week-old calves infected with E. coli O157:H7. Our objective was to determine if E. coli O157:H7 induce A/E lesions in neonatal calves. Colostrum-deprived calves (< 12-h-old) were bottle-fed with antibiotic-free milk replacer containing 10(10) colony forming units (CFU) of O157:H7 (SLT-I+, SLT-II+) or nonpathogenic E. coli, necropsied 18 h postinfection and their intestines examined histologically. Bacterial attachment, effacement of microvillous borders, and destruction of epithelium were observed in the intestines of the neonatal ...Continue Reading

Citations

Apr 20, 2001·Critical Reviews in Biotechnology·S ParkR A Durst
Sep 4, 2008·Infection and Immunity·Pablo NartJ Christopher Low
Dec 17, 2014·Foodborne Pathogens and Disease·Krysty D MunnsTim A McAllister
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·María A RendónJorge A Girón
Jan 5, 2014·The Journal of Microbiology·Moo-Seung LeeVernon L Tesh
Feb 12, 2009·FEMS Microbiology Reviews·Roberto M La RagioneAndrew D Wales
Jan 25, 2006·Journal of Applied Microbiology·A I EtcheverríaA E Parma
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·Stuart W NaylorJ Christopher Low
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