PMID: 9419769Jul 1, 1994Paper

Pathogenesis of ovarian cancers

Journal of the Society for Gynecologic Investigation
A BerchuckR. C. Bast

Abstract

To review our current understanding of the molecular genetic events involved in the development of epithelial ovarian cancers. Molecular biologic techniques have been used to examine the role of growth-stimulatory genes (oncogenes) and -inhibitory genes (tumor suppressors) in ovarian cancer. A number of different peptide growth factors and their receptors are expressed by normal and malignant ovarian epithelial cells. However, the role, if any, of growth factors in ovarian carcinogenesis or maintenance of the transformed phenotype remains unknown. Amplification and overexpression of the HER-2/neu and c-myc oncogenes occur in a significant fraction of epithelial ovarian cancers (20-30%). Overexpression of HER-2/neu has correlated with poor survival in some studies, whereas c-myc amplification is more common in serous cancers. Mutation of the K-ras oncogene frequently occurs in borderline ovarian tumors, but is less common in invasive epithelial ovarian cancers. Mutation of the p53 tumor suppressor gene occurs in approximately half of advanced (stage III/IV) ovarian cancers and in 15% of early (stage IA/IB) cases. Most recently, preliminary studies have focused on the role of other tumor suppressor genes, cyclins, WAF1, and DNA m...Continue Reading

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Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. KoulÅ. Borg Å
Feb 10, 2009·European Journal of Clinical Investigation·A C WangP S Liu
Dec 8, 2010·Proteomics. Clinical Applications·Anette Lykke PetriClaus Høgdall
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Jul 22, 2009·Journal of Translational Medicine·Ki Hyung KimAyesha B Alvero

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