PMID: 3762654Jun 1, 1986Paper

Pathogenesis of paracoccidioidomycosis: a histopathological study of the experimental murine infection

Mycopathologia
V BedoyaAngela Restrepo

Abstract

The pathogenesis of primary pulmonary P. brasiliensis infection, the systemic dissemination which followed, and the histopathology of the main organs involved was studied in a murine model of chronic paracoccidioidomycosis. Adult male BALB/C mice, were challenged intranasally with 26 X 10(-6) viable P. brasiliensis yeast cells. We inoculated 86 animals which were sacrificed from 0 h to 20 weeks. As controls, 11 mice were instilled with saline solution, and 48 with 26 X 10(-6) heat-killed. P. brasiliensis yeast cells. None of the animals receiving saline, exhibited pathologic alterations; 11.6% of those inoculated with the heat-killed cells, revealed mild, transitory acino-pulmonary neutrophilic infiltrates. The animals infected with viable cells, developed a systemic process affecting mainly the lungs (46.5%), liver (18.6%), lymph-nodes (18.6%), and spleen (3.5%). In this group of animals, lung lesions were detected regularly at all time periods from 3 h to 20 weeks. A multiple bronchopneumonic process was initially observed at 6 h, reached its maximum intensity around the third day, subsided thereafter but did not disappear and reactivated after the fifth week to become stationary until the end of experiments. Dissemination to...Continue Reading

References

Feb 28, 1979·Mycopathologia·V L CalichC R Paula
Apr 15, 1978·Gastrointestinal Radiology·H A Shaffer, R B Harrison
Mar 1, 1977·The Tohoku Journal of Experimental Medicine·S YasuokaE Tsubura
Oct 1, 1974·Cancer·R J Lukes, R D Collins
May 1, 1972·Infection and Immunity·L I Linares, L Friedman
Aug 1, 1980·Journal of Clinical Microbiology·A Restrepo, B E Jiménez
Jan 1, 1980·Journal of Steroid Biochemistry·H A EloP J Tuohimaa
Jan 1, 1962·Pathologia et microbiologia·M STRAUB, J SCHWARZ

❮ Previous
Next ❯

Citations

Feb 26, 2004·Medical Mycology·Maria Fernanda Reis Gavazzoni DiasWanderley De Souza
Jun 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·J G McEwenA Restrepo
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·S RestrepoA Restrepo
Dec 5, 2015·Frontiers in Microbiology·Haroldo C de OliveiraMaria J S Mendes-Giannini
Aug 13, 2004·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Maria Fernanda R G DiasWanderley de Souza
Feb 21, 2006·FEMS Immunology and Medical Microbiology·Sheyla M R C BonfimMaristela Pereira
Apr 11, 2008·FEMS Immunology and Medical Microbiology·Angel GonzálezLuz E Cano
Apr 12, 2008·Medical Mycology·Maria Fernanda Reis Gavazzoni DiasWanderley De Souza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.