Pathogenesis of Portal Cavernoma Cholangiopathy: Is it Compression by Collaterals or Ischemic Injury to Bile Ducts During Portal Vein Thrombosis?

Journal of Clinical and Experimental Hepatology
Pankaj Puri

Abstract

The pathogenesis of portal cavernoma cholangiopathy (PCC) is important as it can impact the choice of treatment modalities. PCC consists of a reversible component, which resolves by decompression of collaterals as well as a fixed component, which persists despite the decompression of collaterals. The reversible component is due to compression by large collaterals located adjacent to the bile duct as well as possibly intracholedochal varices. The fixed component is likely to be due to ischemia at the time of portal vein thrombosis, local ischemia by compression as well as encasement by a solid tumor-like cavernoma comprising of fibrous hilar mass containing multiple tiny collateral veins rather than markedly enlarged portal collaterals. Although cholangiographic abnormalities in portal hypertension are common, the prevalence of symptomatic PCC is low. This is likely to be related to the cause of portal hypertension, the duration of portal hypertension and possibly the pattern of occlusion of the splenoportal axis. There may possibly be higher prevalence of symptomatic PCC in extension of the thrombosis to the splenomesentric veins.

References

Sep 1, 1988·The Japanese Journal of Surgery·Y Saji
May 1, 1993·AJR. American Journal of Roentgenology·L G CraboP C Freeny
May 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M S KhurooM I Boda
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ShahR J Groszmann
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ekataksin
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bertrand CondatDominique Valla
May 1, 1953·The Anatomical Record·H ELIAS, D PETTY
Jan 21, 2004·Journal of Gastroenterology and Hepatology·Showkat Ali ZargarHakim Mohamad Shafi
Mar 31, 2004·Clinical Imaging·S NovellasJ-N Bruneton
Dec 22, 2004·Journal of Gastroenterology and Hepatology·Ritu KhareVinay K Kapoor
Dec 16, 2006·Gut·Radha K DhimanSudha Suri
Jun 27, 2007·Annals of Surgery·Eric VibertDenis Castaing
Feb 14, 2008·European Journal of Pediatrics·Wael El-MatarySimon C Ling
Jul 28, 2009·Gastrointestinal Endoscopy·Malay Sharma, Amit Pathak
Dec 17, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anil Kumar AgarwalS P Girish
Dec 25, 2010·Journal of Indian Association of Pediatric Surgeons·K L N Rao, B R Thapa
Dec 25, 2010·World Journal of Gastroenterology : WJG·Christian EipelBrigitte Vollmar
Jan 29, 2011·Gut·Elba LlopJuan Carlos García-Pagán
Mar 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W R R FaridG Kazemier
Feb 11, 2012·Annals of Surgery·Juliette C SliekerGeert Kazemier
Jun 8, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Somnath ChattopadhyaySamiran Nundy
Jul 19, 2012·World Journal of Gastroenterology : WJG·Ozgur Harmanci, Yusuf Bayraktar

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Citations

Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Radha K DhimanJang B Dilawari
May 25, 2018·AJR. American Journal of Roentgenology·Reena C JhaAmit Dinesh Kalaria
Oct 26, 2018·American Journal of Clinical Pathology·Meredith E PittmanJose Jessurun
Sep 28, 2016·World Journal of Gastroenterology : WJG·Mohammad S KhurooMehnaaz S Khuroo
Oct 25, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Anupam Kumar SinghJayanta Samanta

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