Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction

Plastic and Reconstructive Surgery
Joan LipaCho Y Pang

Abstract

Capsular contracture is the main complication in postmastectomy tissue expander and implant breast reconstruction in patients requiring radiotherapy. There is evidence that the wingless signaling pathway plays a central role in the pathogenesis of fibroproliferation in fibromatosis and hyperplastic skin wounds, involving multiple linked events leading to up-regulation of target genes and fibroproliferation. Here, the authors tested their hypothesis that the wingless signaling pathway may also regulate radiotherapy-induced fibroproliferation in capsular tissue around expanders/implants in breast reconstruction. Biopsies of the periprosthetic capsule were obtained from patients undergoing bilateral expander breast reconstruction in which one side was radiated and the other side was not radiated. Capsular biopsies were snap-frozen and stored at -80 degrees C for Western blot assays to determine protein content of phospho-glycogen-synthase-kinase-3beta (phospho-GSK-3beta), total GSK-3beta, beta-catenin, cyclooxygenase-2 (COX-2), and collagen types I and III (n = three to five patients), normalized to beta-actin. Immunostaining for beta-catenin in radiated and nonradiated capsular tissue was also performed. Slides were scanned and a...Continue Reading

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Citations

Sep 29, 2012·Plastic and Reconstructive Surgery·Akhil K SethJohn Y S Kim
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Diego RibuffoAlberto Rainer
Dec 17, 2014·Plastic and Reconstructive Surgery. Global Open·Ronaldo Scholze WebsterPedro Bins Ely
Mar 11, 2018·Journal of Plastic Surgery and Hand Surgery·Jae Bong KimJung Dug Yang
Jul 9, 2014·Annals of Plastic Surgery·Joshua M AdkinsonRobert X Murphy
Feb 26, 2020·Plastic and Reconstructive Surgery·Giuseppe A G LombardoFerdinando Nicoletti
Dec 28, 2017·Plastic and Reconstructive Surgery·Marilena GaldieroGiovanni Francesco Nicoletti
Jan 17, 2020·Plastic and Reconstructive Surgery. Global Open·Kristina M CrawfordMatthew R Endara
Dec 5, 2018·Plastic and Reconstructive Surgery·Farhad AzimiAndrew J Spillane
Jun 23, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Yoshiko IwahiraHiromi Sanada
Jul 28, 2021·Aesthetic Plastic Surgery·Andreas LarsenMikkel Herly
May 14, 2020·Breast Care·Christiane MatuschekWilfried Budach

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