PMID: 7581269Jun 1, 1995Paper

Pathogenesis of Rhodococcus equi infection in mice: roles of virulence plasmids and granulomagenic activity of bacteria

FEMS Immunology and Medical Microbiology
S TakaiA Nakane

Abstract

Virulence of Rhocococcus equi ATCC 33701 and its plasmid-cured derivative ATCC 33701P- was compared in BALB/c and C3H/HeJ mice in terms of bacterial growth kinetics and histological changes in the liver, spleen and lungs, and humoral immune responses. Injection with a sublethal dose of 10(6) ATCC 33701 in mice resulted in microabscess formation after rapid multiplication in the liver and spleen by day 4, and then the bacteria were gradually eliminated with the formation of granuloma and the production of specific antibodies against 15- to 17-kDa antigens of the virulent bacteria. By contrast, ATCC 33701P- was avirulent as shown by early elimination of viable bacteria and no evidence of net multiplication in the organs. Histopathological changes consisted of only slight, transient infiltration of neutrophils and macrophages in the liver. Although live ATCC 33701P- did not evoke any humoral or histological responses in the mice, a large inoculum (10(8)) of killed ATCC 33701 and ATCC 33701P- resulted in the formation of granuloma in the liver and accelerated extramedullary hemopoiesis in the spleen. These results suggest that the pathogenesis of R. equi infection involves at least two important virulence determinants, both of whic...Continue Reading

References

May 1, 1978·Journal of General Microbiology·M MitsuyamaS Shimotori
Dec 1, 1991·Journal of Clinical Microbiology·O Tkachuk-Saad, J Prescott
Aug 30, 1991·Veterinary Microbiology·J A YagerB A Croy
Jan 1, 1991·Clinical Microbiology Reviews·J F Prescott
Mar 1, 1991·Journal of Clinical Microbiology·S TakaiS Tsubaki
Feb 1, 1990·The American Review of Respiratory Disease·Y Sibille, H Y Reynolds
Dec 1, 1989·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·M D BartonD E Minnikin
Aug 1, 1987·Veterinary Microbiology·J A Yager
Oct 1, 1966·The Journal of Experimental Medicine·G B MackanessF M Collins
Jan 1, 1980·Comparative Immunology, Microbiology and Infectious Diseases·G S ElissaldeJ A Walberg
Jul 1, 1993·Journal of Clinical Microbiology·S TakaiT Sekizaki
Jan 1, 1993·Annual Review of Immunology·S H Kaufmann
Jan 1, 1996·Trends in Microbiology·D M Mosser, M K Hondalus
Jul 1, 1964·The Journal of Experimental Medicine·G B MACKANESS
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

❮ Previous
Next ❯

Citations

Jan 1, 1996·Trends in Microbiology·D M Mosser, M K Hondalus
May 3, 2000·International Journal of Food Microbiology·S BenoitA Hartke
Jun 16, 1997·Veterinary Microbiology·M K Hondalus
Nov 19, 2011·Journal of Veterinary Internal Medicine·S GiguèreN M Slovis
Jul 26, 2000·Journal of the American Veterinary Medical Association·R J MartensS W Lingsweiler
Aug 27, 2010·Veterinary Immunology and Immunopathology·M C HellerJ L Watson
Jun 20, 2014·Equine Veterinary Journal·C GilesM D Barton
May 24, 2014·Veterinary Microbiology·Patricia González-IglesiasJosé A Vazquez-Boland
Dec 26, 2001·FEMS Microbiology Letters·M W Mangan, W G Meijer
Mar 24, 2016·PloS One·Carla GilesThiru Vanniasinkam
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia A DarrahDavid M Mosser
Jul 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V VulloS Delia
May 21, 2009·FEMS Microbiology Reviews·Kristine von Bargen, Albert Haas
Apr 1, 1996·Journal of Clinical Microbiology·S TakaiT Sekizaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.