Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection

Annual Review of Pathology
Abha SahniDavid H Walker

Abstract

Obligately intracytosolic rickettsiae that cycle between arthropod and vertebrate hosts cause human diseases with a spectrum of severity, primarily by targeting microvascular endothelial cells, resulting in endothelial dysfunction. Endothelial cells and mononuclear phagocytes have important roles in the intracellular killing of rickettsiae upon activation by the effector molecules of innate and adaptive immunity. In overwhelming infection, immunosuppressive effects contribute to the severity of illness. Rickettsia-host cell interactions involve host cell receptors for rickettsial ligands that mediate cell adhesion and, in some instances, trigger induced phagocytosis. Rickettsiae interact with host cell actin to effect both cellular entry and intracellular actin-based mobility. The interaction of rickettsiae with the host cell also involves rickettsial evasion of host defense mechanisms and exploitation of the intracellular environment. Signal transduction events exemplify these effects. An intriguing frontier is the array of rickettsial noncoding RNA molecules and their potential effects on the pathogenesis and transmission of rickettsial diseases.

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Citations

Jan 8, 2020·Infection and Immunity·Na JiaWu-Chun Cao
Nov 5, 2019·Frontiers in Immunology·Madison R RoganJere W McBride
Aug 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hwan Keun KimOlaf Schneewind
Oct 23, 2020·PLoS Neglected Tropical Diseases·Anke Osterloh
Feb 13, 2021·Research and Reports in Tropical Medicine·Maria A Caravedo MartinezLucas S Blanton
Mar 2, 2021·Frontiers in Immunology·Nathalie Boulanger, Stephen Wikel
Apr 4, 2021·Microorganisms·Imran Farooq, Tara J Moriarty
Mar 12, 2021·Pathogens and Disease·Oliver H Voss, M Sayeedur Rahman
Mar 14, 2021·Parasite Immunology·Shahid KarimKhemraj Budachetri
Apr 29, 2021·Pathogens and Disease·Wan-Yi YenHwan Keun Kim
May 7, 2021·MSphere·Mark L GuillotteAbdu F Azad
Apr 1, 2021·The American Journal of Forensic Medicine and Pathology·Ryan BlumenthalJacqueline Weyer
Nov 3, 2021·Molecular Microbiology·Mustapha DahmaniSean P Riley

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Methods Mentioned

BETA
GTPase

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