PMID: 2499135Mar 1, 1989Paper

Pathogenesis of scrapie in mice after intragastric infection

Virus Research
R H Kimberlin, C A Walker

Abstract

Infection via the gastrointestinal tract is likely to be a natural route of scrapie infection in sheep. This paper describes the pathogenesis of the 139A strain of scrapie introduced intragastrically (i.g.) into CW mice. There was an almost immediate uptake of infectivity and onset of replication in Peyer's patches which preceded replication in spleen. Splenectomy had no effect on incubation period suggesting that, in contrast to the intraperitoneal route, the spleen plays little or no role in the pathogenesis of 139A scrapie administered intragastrically. Replication in the CNS was first detectable in the thoracic spinal cord and later in brain. The evidence is consistent with neural spread of infection from the gastrointestinal tract, via the enteric and sympathetic nervous systems to spinal cord. Neuroinvasion may be initiated either via infection of Peyer's patches or directly by infection of nerve endings in the gut wall. The latter possibility means that pathogenesis may be completely independent of the lymphoreticular system.

References

Feb 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·E E Manuelidis, L Manuelidis
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·R H Kimberlin, C A Walker
Mar 1, 1989·Virus Research·R H Kimberlin, C A Walker
Jan 1, 1989·Diseases of the Colon and Rectum·A Sonnenberg, T R Koch
Nov 1, 1985·The Journal of Infectious Diseases·S B PrusinerM P Alpers
Dec 1, 1969·The Journal of Infectious Diseases·R F MarshR P Hanson
Jan 1, 1980·Neuroscience·J B Furness, M Costa
Feb 1, 1984·The Journal of General Virology·B EhlersH Diringer
Aug 1, 1984·The Journal of General Virology·B Ehlers, H Diringer
Apr 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·H L AmyxW E Greer
Nov 1, 1982·The Journal of Infectious Diseases·W J HadlowR E Race
Aug 1, 1980·The Journal of Infectious Diseases·C J GibbsD C Gajdusek
Oct 1, 1962·Journal of Comparative Pathology·I ZLOTNIK, J C RENNIE

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Citations

Mar 1, 1989·Virus Research·R H Kimberlin, C A Walker
Apr 1, 1993·Veterinary Microbiology·J R ScottH Fraser
Apr 6, 2004·Advanced Drug Delivery Reviews·Fang-Ping Huang, G Gordon MacPherson
Jun 5, 1998·Immunology Today·N A MabbottM E Bruce
Aug 7, 2002·Seminars in Immunology·Neil A Mabbott, Moira E Bruce
Apr 3, 1999·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·S BrandnerA Aguzzi
Jul 8, 2000·Microbes and Infection·M Glatzel, A Aguzzi
Aug 30, 2008·Environmental Science & Technology·Glen T HinckleyJoel A Pedersen
Jun 18, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L J M van KeulenF G van Zijderveld
Jun 18, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ebbe Dickmeiss, Jan Gerstoft
Sep 21, 2004·Nature Reviews. Microbiology·Claudio Soto
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·A Aguzzi, C Weissmann
Oct 29, 2000·Neuropathology and Applied Neurobiology·D A Hilton
Dec 18, 1997·The New England Journal of Medicine·A M Haywood
Jan 11, 2011·Journal of Toxicology and Environmental Health. Part a·Christopher J JohnsonJudd M Aiken
Dec 1, 1990·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A Bundza
Jun 6, 1994·Annals of the New York Academy of Sciences·H DiringerU Oberdieck
Jan 1, 1991·Brain Pathology·G A WellsI S McGill
Nov 19, 2010·Journal of Virology·Nathaniel D DenkersEdward A Hoover
Nov 19, 2010·Journal of Virology·Ciriaco LigiosChristina J Sigurdson
Feb 16, 2007·Journal of Virology·Anthony E Kincaid, Jason C Bartz
Jun 28, 2003·Journal of Virology·Alana M ThackrayRaymond Bujdoso
Mar 15, 2001·Gut·A N Shmakov, S Ghosh
Jul 24, 2010·Interdisciplinary Perspectives on Infectious Diseases·Sílvia SisóMartin Jeffrey
May 18, 2004·The Journal of Clinical Investigation·Achim ThomzigMichael Beekes
Jul 10, 2007·PLoS Pathogens·Christopher J JohnsonJudd M Aiken
Feb 10, 2012·PLoS Pathogens·Cyrus BettChristina J Sigurdson
Feb 24, 2012·PLoS Pathogens·Rocio Castro-SeoanePeter-Christian Klöhn
Mar 12, 2010·Uirusu·Ken'ichi HagiwaraKentaro Hanada
May 1, 2009·Emerging Infectious Diseases·Rachel C AngersGlenn C Telling
Jan 25, 2013·Viruses·Barry M Bradford, Neil A Mabbott
Nov 6, 1998·Brain Pathology·A J RaeberA Aguzzi
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paul BrownMaurizio Pocchiari
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·N BonsP Brown
Dec 16, 1998·Research in Immunology·D Dormont

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