Pathogenesis of the eosinophilic pleural effusions

Current Opinion in Pulmonary Medicine
Ioannis Kalomenidis, Richard W Light

Abstract

Eosinophilic pleural effusions (EPE) are defined as those that contain at least 10% eosinophils. EPEs account for 5 to 16% of exudative pleural effusions. However, their pathogenesis is poorly understood. The purpose of this review is to discuss the mechanisms that lead to eosinophilic pleural inflammation. Eosinophilic pleural effusions are caused by the presence of air or blood or both in the pleural space, infectious or other inflammatory diseases, malignancy, pulmonary emboli, asbestos exposure, and drug reactions. Differences in the clinical features suggest that a variety of mechanisms operate to induce eosinophilic pleural inflammation and pleural fluid accumulation. Human and animal studies indicate that interleukin (IL)-5 is an important common contributor of different pathogenetic pathways. The possible role of other cytokines, chemokines, and adhesion molecules in the development of EPE is under investigation. Understanding the pathogenesis of EPE will permit the development of novel therapies for the persistent, symptomatic, posttraumatic and idiopathic EPE. Anti-IL-5 treatment is an interesting option that requires further research.

References

Oct 1, 1992·The Journal of Experimental Medicine·N JonjićA Mantovani
May 17, 1991·European Journal of Pharmacology·M C LimaB B Vargaftig
Jan 1, 1991·International Archives of Allergy and Applied Immunology·C P PasqualeR S Cordeiro
Apr 1, 1989·European Journal of Immunology·J M WangA Mantovani
Jul 1, 1993·Clinical and Experimental Immunology·L SchandenéM Goldman
May 29, 1998·The New England Journal of Medicine·M E Rothenberg
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G HalldénJ Lundahl
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·S D RobinsonR O Hynes
Oct 27, 1999·Journal of Clinical Immunology·M E RothenbergP S Foster
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A KleinM M Teixeira
Aug 26, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·T S Fröde-Saleh, J B Calixto
Feb 13, 2001·Clinical and Experimental Immunology·H TaniguchiY Nawa
Feb 24, 2001·Bratislavské lekárske listy·M Buc, M Bucova
Jun 21, 2001·American Journal of Respiratory Cell and Molecular Biology·C Bandeira-MeloP F Weller
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A KleinM M Teixeira
Aug 24, 2001·Internal Medicine·H IshiiY Nawa
Dec 1, 2001·American Journal of Respiratory Cell and Molecular Biology·C PenidoP T Bozza
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Steve N GeorasCristiana Stellato
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·James G Zangrilli
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Hitoshi KatayamaKoichi Hirai
Jun 11, 2002·Current Opinion in Pulmonary Medicine·Carolyn S Grove, Y C Gary Lee
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Marsha Wills-Karp, Monica Chiaramonte
Apr 10, 2003·Chest·Roslyn F Schneider, Mark J Rosen
May 27, 2003·The European Respiratory Journal·Y NishigakiK Kikuchi
Jun 14, 2003·Current Opinion in Pulmonary Medicine·Ioannis Kalomenidis, Richard W Light
Jul 11, 2003·Chest·Ioannis KalomenidisRichard W Light

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Citations

Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ioannis KalomenidisCharis Roussos
Jan 30, 2009·Journal of Medical Case Reports·Carlos Fernández de LarreaJacobus H de Waard
Oct 27, 2010·CytoJournal·Namrata SetiaPantanowitz Liron
Aug 13, 2011·Archivos de bronconeumología·Lucía FerreiroLuis Valdés
Dec 6, 2011·Revue de pneumologie clinique·C BallyP-R Burgel
Jan 17, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Qiang LiKeiji Kawamoto
May 10, 2006·British Journal of Haematology·Ayalew TefferiAnimesh Pardanani
Jul 28, 2016·The Clinical Respiratory Journal·Thanasis VoulgarisMarios Froudarakis
May 18, 2011·Respiration; International Review of Thoracic Diseases·Yuji Oba, Tareq Abu-Salah
Feb 12, 2011·Respiration; International Review of Thoracic Diseases·Austin N KirschnerTomasz J Kuzniar
Mar 3, 2011·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Emmet E McGrath, Paul B Anderson
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Fang-Yeh ChuMing-Jang Su
Apr 19, 2020·BMJ Case Reports·Abdullah Al-AbchaAhmad Alratroot
Jul 6, 2021·World Journal of Clinical Cases·Tao FanCheng-Wei Wang
Jul 15, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Stavros TryfonGeorge Ismailos
Jun 5, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Regitze Sølling WilsPeter Møller

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