PMID: 3319809Jan 1, 1987Paper

Pathogenesis of the mucosal hyperplasia in self-filling blind loops of rat jejunum: a morphometric study in germ free animals

Gut
H MengeE O Riecken

Abstract

Bacterial overgrowth and high intraluminal concentrations of deconjugated bile acids are thought to be responsible for mucosal hyperplasia in self-filling blind loops of rat jejunum. To investigate this hypothesis further we have assessed the three dimensional architecture of these loops created in germ free animals without or with di- or mono-association of different bacterial species. It was found that mucosal hyperplasia develops in the absence of any bacterial contamination and that bacterial association does not lead to a more pronounced mucosal proliferation. This implies that other mechanisms provoke this morphological phenomenon. Increased bulk contents in these loops or immunological events are probably the most likely explanation.

References

Aug 1, 1976·The Australian Journal of Experimental Biology and Medical Science·V BurkeA Malajczuk
Oct 1, 1975·Australian and New Zealand Journal of Medicine·V BurkeA Malajczuk
Nov 26, 1975·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R BlochE O Riecken
Nov 1, 1974·The American Journal of Clinical Nutrition·T Midtvedt
Feb 1, 1968·Gut·M J Hill, B S Drasar
Oct 1, 1982·Infection and Immunity·M A CarlomagnoA Gimeno
Aug 1, 1980·The Journal of Clinical Investigation·S P RiepeD H Alpers
May 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·G JönssonT Midtvedt

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Citations

Jun 1, 1993·Scandinavian Journal of Gastroenterology·J D SchulzkeE O Riecken

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