Pathogenesis of the neurotoxicity caused by anti-GD2 antibody therapy

Journal of the Neurological Sciences
N YukiS Handa

Abstract

After treatment of melanomas with anti-GD2 monoclonal antibody (MAb) (14G2a), some patients develop sensorimotor demyelinating polyneuropathy with and without the syndrome of inappropriate antidiuretic hormone (SIADH). To clarify what causes the neurotoxicity of anti-GD2 MAb, we investigated the immunohistochemical localization of GD2 in the human nervous system. Anti-GD2 MAb (14G2a) reacted with the myelin sheaths in the peripheral nerves as well as with the pituicyte cytoplasm in the posterior lobe of the pituitary gland. We assume that the binding of anti-GD2 MAb to peripheral nerve myelin and the pituicytes in the posterior pituitary causes sensorimotor demyelinating neuropathy and SIADH.

Citations

Dec 18, 2007·Expert Reviews in Molecular Medicine·Erik JohnsonPaul M Sondel
Oct 22, 2013·Nature Biotechnology·Christian S Hinrichs, Nicholas P Restifo
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kaci L OsengaUNKNOWN Children's Oncology Group
May 17, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Pam FredmanThomas Brezicka
Nov 11, 2010·Rinshō shinkeigaku = Clinical neurology·Manabu InoueHiroshi Shibasaki
Oct 4, 2011·Vaccine·Jamie Heimburg-MolinaroKate Rittenhouse-Olson
Jan 29, 2013·International Journal of Cancer. Journal International Du Cancer·Marie VincentYannick Jacques
May 4, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonino UnciniNobuhiro Yuki
Jul 16, 2005·Ocular Immunology and Inflammation·Charles E Thirkill
Apr 23, 2013·Rinshō shinkeigaku = Clinical neurology·Takenobu MurakamiYoshikazu Ugawa
May 4, 2016·Melanoma Research·Shu F Lee, Victoria Atkinson
Aug 30, 2020·FEBS Letters·John YuAlice L Yu
Jun 27, 2019·International Journal of Cancer. Journal International Du Cancer·Julien FleurenceStéphane Birklé
Feb 6, 2017·Journal of Immunology Research·Julien FleurenceStéphane Birklé
Jul 23, 2018·Journal of Experimental & Clinical Cancer Research : CR·Michelle H TownsendKim L O'Neill
Mar 1, 2005·Journal of Neuro-oncology·A RousseauM Sanson
Sep 25, 2002·Physiological Reviews·Linda R Watkins, Steven F Maier
May 30, 2019·Clinical & Translational Immunology·Michael P BrownTessa Gargett
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nidia Alvarez-RuedaStéphane Birklé
Jun 18, 2021·Biologics : Targets & Therapy·Wayne L Furman

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