Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause.

Diabetologia
R Taylor

Abstract

The metabolic abnormalities of type 2 diabetes can be reversed reproducibly by bariatric surgery. By quantifying the major pathophysiological abnormalities in insulin secretion and insulin action after surgery, the sequence of events leading to restoration of normal metabolism can be defined. Liver fat levels fall within days and normal hepatic insulin sensitivity is restored. Simultaneously, plasma glucose levels return towards normal. Insulin sensitivity of muscle remains abnormal, at least over the weeks and months after bariatric surgery. The effect of the surgery is explicable solely in terms of energy restriction. By combining this information with prospective observation of the changes immediately preceding the onset of type 2 diabetes, a clear picture emerges. Insulin resistance in muscle, caused by inherited and environmental factors, facilitates the development of fatty liver during positive energy balance. Once established, the increased insulin secretion required to maintain plasma glucose levels will further increase liver fat deposition. Fatty liver causes resistance to insulin suppression of hepatic glucose output as well as raised plasma triacylglycerol. Exposure of beta cells to increased levels of fatty acids,...Continue Reading

Associated Clinical Trials

Oct 6, 2011·Simona Frontoni

References

Jul 1, 1977·The Journal of Clinical Investigation·J D McGarryD W Foster
Aug 1, 1994·Pediatric Annals·M C Moffitt
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LeeR H Unger
Nov 15, 1996·The Journal of Clinical Investigation·L S SidossisR R Wolfe
Apr 1, 1997·QJM : Monthly Journal of the Association of Physicians·A J TurnbullM F Bassendine
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Anneli Seppälä-LindroosHannele Yki-Järvinen
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Parag SinghalRoy Taylor
Nov 28, 2002·American Journal of Physiology. Endocrinology and Metabolism·P E CareyR Taylor
Jul 2, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E R GibneyM Elia
Apr 10, 2004·The Journal of Biological Chemistry·Anne BoucherChristopher B Newgard
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Feb 4, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ayako SuzukiKeith Lindor
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
May 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Gianluca PerseghinLivio Luzi
May 19, 2006·Journal of Gastroenterology and Hepatology·Chalamalasetty Sreenivasa BabaGourdas Choudhuri
Jun 29, 2006·Diabetes·Caterina GuidoneGeltrude Mingrone
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valerio NobiliPaul Angulo
Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
Nov 9, 2006·American Journal of Physiology. Endocrinology and Metabolism·Leena JuurinenHannele Yki-Järvinen
Dec 1, 2006·The New England Journal of Medicine·Renata BelfortKenneth Cusi
Mar 1, 2007·Diabetes Care·Gianluca PerseghinLivio Luzi
Aug 2, 2007·Diabetes Care·Maarten E TushuizenMichaela Diamant
Jan 24, 2008·JAMA : the Journal of the American Medical Association·John B DixonMargaret Anderson

❮ Previous
Next ❯

Citations

Apr 6, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E LerchbaumW März
Apr 1, 2011·The Proceedings of the Nutrition Society·Ala Szczepura
Mar 12, 2009·Current Opinion in Lipidology·Georg Lietz, John Hesketh
Mar 16, 2011·International Journal of Clinical Practice·S KumarK Khunti
Jan 29, 2011·Journal of Obesity·Simon N DankelLena Burri
Jan 12, 2012·Journal of Obesity·Jennie C Brand-MillerStephen Colagiuri
Jul 26, 2012·Endocrine Reviews·Harpal S RandevaHendrik Lehnert
Jul 5, 2013·PloS One·Franck TourniaireJean-Francois Landrier
Sep 23, 2011·European Journal of Endocrinology·Elisabeth LerchbaumBarbara Obermayer-Pietsch
Mar 28, 2012·The Libyan Journal of Medicine·Dhastagir S SheriffThiruvagounder Manopriya
May 30, 2009·Acta Diabetologica·Stephan F E Praet, Luc J C van Loon
Dec 2, 2011·Journal of Nutrition and Metabolism·Delphine Fradin, Pierre Bougnères
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
May 7, 2010·Current Opinion in Anaesthesiology·Patrick J Neligan
May 8, 2009·World Journal of Surgery·John B Dixon
Feb 19, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·George A KrausAaron Kempema
Aug 28, 2014·BMC Medicine·Naveed Sattar, Jason M R Gill
Jan 17, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·S StevenR Taylor
Jun 9, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·H ShethJ Burn
Nov 5, 2011·Journal of Clinical Anesthesia·Claire L DonohoeJohn V Reynolds
Jul 27, 2010·Maturitas·Thomas M BarberJonathan Levy
Jul 4, 2009·Seminars in Pediatric Surgery·John B DixonMaureen Dixon
Jul 25, 2009·Molecular and Cellular Endocrinology·John B Dixon
Feb 19, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S PettaA Craxì
Dec 15, 2015·Trials·Stefano BalducciUNKNOWN Italian Diabetes and Exercise Study 2 (IDES_2) Investigators
Jan 16, 2016·Journal of Diabetes Research·Claudia P OliveiraAline Marcadenti
Aug 17, 2014·Biochimica Et Biophysica Acta·Nanda GrubenMarten H Hofker
Feb 17, 2009·Diabetes/metabolism Research and Reviews
Jun 19, 2013·The British Journal of Dermatology·P Coto-SeguraE Coto
Jul 14, 2011·The British Journal of Surgery·S Ikramuddin, H Buchwald
Oct 13, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·N Sattar
Sep 25, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·R S Bhopal
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nazim GhouriNaveed Sattar
Oct 19, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·R Taylor
Aug 6, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E PaschettaG Musso
Jun 16, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·S StevenR Taylor
Nov 21, 2014·Journal of Diabetes Investigation·Søs Skovsø
Mar 31, 2016·International Journal of Molecular Sciences·David HoughtonMichael Trenell
Aug 19, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·S StevenR Taylor

❮ Previous
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