Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa

JAMA Dermatology
Anna CampanatiRoberto Di Primio

Abstract

Hidradenitis suppurativa (HS) is a disease of the terminal hair follicle in apocrine gland-enriched skin areas, where immunobiology dysregulation of mesenchymal stem cells (MSCs) may have a key role. To investigate the MSC profile in patients with HS and in healthy controls. In this prospective case-control study, patients with HS were recruited from the Dermatological Clinic at the Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy. Biopsy specimens were analyzed at the Histology Section of the Department of Clinical and Molecular Sciences. Participants included 11 patients with HS and 9 healthy controls, who were recruited into the study between January 20, 2015, and September 20, 2016, and underwent punch biopsy from axillary skin. None of the participants had received any antibiotics (systemic or topical therapy) within almost 12 weeks before the study. The immunophenotypic profile of MSCs was characterized following the minimal criteria established by the International Society for Cellular Therapy for the identification of MSCs. Levels of 12 cytokines belonging to helper T-cell subtypes 1, 2, and 17 pathways were examined on the secretome of isolated cells by enzyme-linked imm...Continue Reading

References

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Citations

Jul 3, 2019·The Australasian Journal of Dermatology·Xueli LiPeng Wang
Nov 12, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A CampanatiM Orciani
Oct 28, 2019·Frontiers in Cell and Developmental Biology·Miriam CaffariniMonia Orciani
Nov 20, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Anna CampanatiAnnamaria Offidani
Nov 5, 2020·International Journal of Molecular Sciences·Martina BonifaziMonia Orciani
Aug 10, 2021·Journal of Cutaneous Medicine and Surgery·Nadia KashetskyJensen Yeung

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