Abstract
Canine steroid-responsive meningitis-arteritis (SRMA) is a systemic inflammatory disease with a predominant manifestation within the cervical meninges, increased immunoglobulin A (IgA) levels in serum and cerebrospinal fluid (CSF), and a shift of the B:T cell ratio towards a higher percentage of B cells. A Th2-dominated immune response associated with SRMA was therefore hypothesised. Pellets of peripheral blood mononuclear cells (PBMNCs) and CSF white blood cells (CSF WBCs) from dogs in the acute phase of SRMA (n=16) and under glucocorticoid treatment for SRMA (n=16) were investigated for interleukin (IL)-2, interferon (IFN)-γ, IL-4, IL-5 and IL-10 mRNA expression by means of reverse-transcriptase real-time polymerase chain reaction. Results were compared with those of dogs with other inflammatory (n=9) and neoplastic disorders (n=10) of the central nervous system. A tendency towards low levels of Th1 response related cytokines (IL-2, IFN-γ) and high IL-4 expression was observed indicating a Th2-skewed immune response. The pronounced IL-4 production may be an important pathogenetic factor for excessive IgA production in the acute phase of SRMA and for those cases under glucocorticoid treatment.
References
Jun 17, 1978·The Veterinary Record·R A Harcourt
Jan 1, 1988·Journal of Veterinary Internal Medicine·S M Meric
Mar 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M L WellmanG J Kociba
Jul 1, 1994·The Journal of Clinical Investigation·F BrièreJ Banchereau
Aug 1, 1995·Immunology Today·A Kelso
Mar 1, 1995·Research in Veterinary Science·A TipoldA Zurbriggen
Aug 1, 1994·Veterinary Immunology and Immunopathology·A TipoldM Vandevelde
Apr 22, 1994·Science·A J RamsayM Kopf
Apr 3, 1993·The Veterinary Record·L Poncelet, M Balligand
Sep 1, 1995·Journal of Veterinary Internal Medicine·A Tipold
Nov 1, 1995·Journal of Clinical Immunology·S RaziuddinM al-Janadi
Oct 31, 1996·Nature·A K AbbasA Sher
Jun 1, 1997·Immunology Today·S Romagnani
Apr 7, 1998·Immunity·A O'Garra
Jul 13, 2000·Veterinary Immunology and Immunopathology·A BarnesS D Carter
Sep 8, 2000·The Journal of Small Animal Practice·S CizinauskasA Tipold
Jul 7, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S YangC McCall
Jul 22, 2004·Annals of the New York Academy of Sciences·Ilia J Elenkov
Mar 25, 2006·Immunology·Alison TaylorCezmi A Akdis
Jul 11, 2006·Journal of the American Animal Hospital Association·Sebastien Behr, Laurent Cauzinille
Jul 18, 2006·The Journal of Small Animal Practice·I A BattersbyK Papasouliotis
Jul 16, 2008·Veterinary Immunology and Immunopathology·M SchwartzA Tipold
Feb 25, 2009·Annals of the New York Academy of Sciences·Ana C LibermanEduardo Arzt
Citations
Apr 29, 2014·PloS One·Visar QeskaAndreas Beineke
Sep 29, 2012·Journal of Neuroinflammation·Arianna MaioliniAndrea Tipold
Feb 6, 2013·BMC Veterinary Research·Arianna MaioliniAndrea Tipold
Nov 12, 2013·Veterinary Immunology and Immunopathology·V QeskaA Beineke
May 1, 2012·Veterinary Immunology and Immunopathology·I SpitzbarthA Beineke
Nov 22, 2011·Veterinary Immunology and Immunopathology·Sarah A MooreMichael J Oglesbee
Mar 4, 2014·The Journal of Small Animal Practice·J H Rose, T R Harcourt-Brown
Oct 14, 2014·Journal of Veterinary Internal Medicine·Y MerblM H Shamir
Jan 25, 2017·Journal of Neuroinflammation·Jessica Freundt-RevillaAndrea Tipold
Dec 20, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Niels GrütznerJörg M Steiner
Jun 9, 2019·Journal of Veterinary Internal Medicine·Jeanie LauKaren R Muñana
Jun 22, 2021·The Veterinary Journal·Emilie Andersen-RanbergHanne Gredal
Jun 22, 2021·The Veterinary Journal·Emilie Andersen-RanbergHanne Gredal
Jul 14, 2014·BMC Veterinary Research·Janina BartelsAndrea Tipold