Pathogenetic heterogeneity of in-stent lesion formation in human peripheral arterial disease

Journal of Vascular Surgery
Shinya InoueHiroshi Shigematsu

Abstract

Intimal hyperplasia is known to promote in-stent restenosis after vascular stent implantation. Although previous studies have presented a variety of evidence that suggests the mechanisms of intimal lesion formation, it is still controversial which factor(s) predominantly contribute to the development of in-stent restenosis. In this study, we hypothesized that heterogeneous mechanisms coexist in the same lesion and then assessed the validity with resected whole arteries with in-stent lesions. Whole arterial specimens with in-stent lesions were surgically resected from five patients who had undergone implantation of a Palmaz-Schatz stent 7 to 19 months previously and were histologically analyzed. For assessment of the pathogenetic heterogeneity of in-stent lesions, we divided each cross section into three parts: the inner intima within 250 microm from the luminal surface (zone A), the area surrounding the stent struts within 250 microm from the strut hole (zone B), and the remaining part of the intimal layer (zone C). We then evaluated cell density, cell replication, and cellular composition in each zone. Cell replication and cellular composition were analyzed with immunohistologic staining with antibodies against proliferating c...Continue Reading

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Citations

Nov 2, 2007·Theoretical Biology & Medical Modelling·Vladimir M Subbotin
Jan 8, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Richard D KenagyThomas N Wight
Dec 12, 2013·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Roberto GandiniGiovanni Simonetti
Jun 6, 2006·Acta Cirúrgica Brasileira·Cyro Castro JúniorMárcio Bastiani Pasa
Dec 9, 2017·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Damianos G KokkinidisEhrin J Armstrong
Dec 10, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Damianos G KokkinidisEhrin J Armstrong
Apr 1, 2012·Journal of the Saudi Heart Association·Hasan KudatYalçın Seyhun
Feb 11, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Dittmar BöcklerJens-Rainer Allenberg
Jan 18, 2006·Journal of Vascular Surgery·Patrick C H HsiehAlexander W Clowes

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