PMID: 9649923Jul 3, 1998Paper

Pathogenetic implications of hyaluronan-induced modification of vascular smooth muscle cell fibrinolysis in diabetes

Coronary Artery Disease
K MarutsukaS Fujii

Abstract

Proteolysis, modulated in part by intramural fibrinolytic system proteins and their inhibitors, appears to influence vascular smooth muscle cell (SMC) migration and proliferation and remodeling of extracellular matrix (ECM). Alterations of fibrinolysis in circulating blood and of proteolysis within vessel walls in experimental animals and patients with diabetes have been associated with accelerated vascular disease. Hyaluronan, a prominent component of ECM in normal vessels, is increased in the tunica media of macroscopically normal arterial vessels from patients with type 2 diabetes. To determine whether hyaluronan alters the expression of the fibrinolytic system protein, plasminogen activator inhibitor type-1 (PAI-1), in human vascular SMCs, thereby potentially accelerating vascular disease in patients with type 2 diabetes. Urokinase-type and tissue-type plasminogen activators (uPA and tPA) and PAI-1 were assayed in vascular SMC conditioned media and in cell lysates, using enzyme-linked immunosorbent assay and western blotting. Hyaluronan increased the 24-h release of PAI-1 into conditioned media in a concentration-dependent and time-dependent manner (1.8-fold compared with control with 1 mg/ml hyaluronan; n = 9, P < 0.01). A...Continue Reading

Citations

Jan 21, 2011·Physiological Reviews·Dianhua JiangPaul W Noble
Jul 18, 2009·Molecular Endocrinology·Ushma R JagFrederick M Stanley
Nov 7, 2015·Advanced Drug Delivery Reviews·Jiurong LiangPaul W Noble
Mar 17, 2016·The Journal of Endocrinology·Erika GalgocziEndre V Nagy
Nov 18, 2005·Lancet·Vincent Falanga
Mar 29, 2002·The Journal of Biological Chemistry·Anthony Igor Vulin, Frederick M Stanley

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