PMID: 22581600May 15, 2012Paper

Pathogenetic justification of statin use in ischaemic stroke prevention according to inflammatory theory in development of atherosclerosis

Neurologia i neurochirurgia polska
Dariusz KotlęgaPrzemysław Nowacki

Abstract

There is an inflammatory component in the pathogenesis of ischaemic stroke, which plays an important role in inducing atherothrombotic and embolic stroke. Statins, HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase inhibitors are widely used in the primary and secondary prevention of ischaemic stroke. It has been proved that beyond their main effect on inhibition of endogenous cholesterol, they also modify the inflammatory process. Additional benefits from the use of statins result from their effect on the immune system. Increased risk of recurrent vascular episodes and risk of death after statin withdrawal in patients with vascular disorders is connected with termination of the anti-inflammatory effect of these drugs. The authors highlight that because of the anti-inflammatory effect of statins it is reasonable to use them in all patients at risk of ischaemic stroke, including those with atrial fibrillation.

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Citations

Mar 2, 2013·Clinical Pharmacology : Advances and Applications·Sayer I Al-AzzamMahmoud Abu-Abeeleh
Mar 19, 2014·Neurologia i neurochirurgia polska·Dariusz KotlęgaPrzemysław Nowacki
Sep 18, 2015·Neurologia i neurochirurgia polska·Dariusz KotlęgaPrzemysław Nowacki
Oct 21, 2020·International Journal of Molecular Sciences·Nikola TułowieckaMałgorzata Szczuko

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