Pathogenetic mechanisms in the Mycoplasma arthritidis polyarthritis of rats.

Rheumatology International
H KirchhoffK Busche

Abstract

Mycoplasma arthritidis is the causative agent of severe polyarthritis in rats and mice, which resembles human rheumatoid arthritis (RA). Several mechanisms are involved in this disease. M. arthritidis releases substances acting on polymorphonuclear granulocytes (PMNs), i.e. oxygen radical formation stimulating substances (500-3,000 daltons), a chemotactic substance (400 daltons) and an aggregating substance (500 daltons). These products were separated from the cell-free culture supernatant by gel chromatography on Sephadex G-15 and G-10 columns. Isolated membranes of M. arthritidis possesses toxic properties for rats, mice, and chicken embryos. Hemolytic activities for sheep red blood cells and toxic effects on fetal rat skin fibroblasts were detected for this 170,000 dalton substance. Cross-reactivity between M. arthritidis and rat tissues was demonstrated in several investigations with polyclonal and monoclonal antibodies. Polyclonal antibodies against M. arthritidis showed a strong reaction in immunofluorescence tests with rat chondrocytes. In Western blot analysis six corresponding protein bands were observed in M. arthritidis membranes and rat chondrocytes, favoring the idea of several shared epitopes. Monoclonal antibodie...Continue Reading

References

Nov 1, 1988·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·K StulleH Kirchhoff

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Citations

Jul 1, 1991·Annals of the Rheumatic Diseases·E JanssonM Karppelin
Jul 1, 1991·Annals of the Rheumatic Diseases·H JulkunenF Fyhrquist
Jun 12, 2002·BMC Musculoskeletal Disorders·Antonio RiveraLilia Cedillo
Apr 1, 1993·FEMS Immunology and Medical Microbiology·E KaklamaniD Trichopoulos
Sep 8, 1998·Veterinary Immunology and Immunopathology·M NiangM L Kaeberle
Dec 10, 1998·Trends in Microbiology·S Rottem, Y Naot
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S RazinY Naot
Feb 1, 1992·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·C T Stadtlander, H L Watson

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