PMID: 8595512Jan 1, 1995Paper

Pathogenic insights from studies of lymphoid tissue from HIV-infected individuals

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
O J CohenA S Fauci

Abstract

Studies of lymphoid tissue from HIV-infected individuals have provided critical insights into the pathogenesis of HIV disease. Systemic dissemination of virus via the lymphatic system occurs at a very early stage after infection. Explosive viral replication within lymphoid tissue ensues, before the development of cell-mediated and humoral immune responses. By the time potent immune responses downregulate viral expression, an immense viral reservoir within lymphoid tissue has already been established. During the stage of dichotomy in viral load between lymph node and peripheral blood, the viral reservoir is maintained by the ability of the follicular dendritic cells (FDC) network to efficiently trap extracellular virions, as well as by immunologic and microenvironmental factors favoring infection of susceptible cells and sequestration of cells already infected. Degeneration of the FDC network and wholesale disruption of lymphoid architecture herald late-stage disease. The dysfunctional lymphoid tissue contributes directly to immunodeficiency and to sharp increases in viral burden and replication as mechanical and immune controls are lost. Studies in HIV-infected long-term nonprogressors indicate that these individuals are able t...Continue Reading

Citations

Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J BlackbournJ A Levy
Jun 5, 1999·AIDS Research and Human Retroviruses·F VerrierM Girard
Oct 3, 2009·AIDS Research and Human Retroviruses·K N ReitanoA S Fauci
Jan 20, 2011·Infection and Immunity·Collin R Diedrich, Joanne L Flynn
Jun 4, 1998·Journal of Neuroimmunology·R M Donahoe, D Vlahov
Apr 26, 2006·Expert Opinion on Investigational Drugs·Priscilla BiswasGiuseppe Tambussi
Dec 5, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R MachucaC Nielsen

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