Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation

Pathology
Sayyed Mohammad Hossein GhaderianReza Akbarzadeh Najar

Abstract

Although the aetiology of varicose veins remains unknown, recent studies have focused on endothelial cell integrity and function. Among the regulatory factors of vessel tone, synthesises, pro- and anti-inflammatory, adhesion molecules and the transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha), which are responsible for recruiting leukocytes, are very important. Investigation in this study focused on the expression of ICAM-1, E-selectin and HIF-1alpha on endothelial cells using immunostaining and RT-PCR in varicose vein specimens compared with controls. Findings of this study showed alterations of the intima, such as focal intimal discontinuity and denudation of endothelium in varicose veins. Based on data derived from immunostaining and RT-PCR, no major differences were identified between ICAM-1 and E-selectin expression in varicose vein specimens compared with controls. In contrast, immunostaining results identified HIF-1alpha expression in five (5/20) varicose vein specimens, whereas no control saphenous vein specimens expressed HIF-1alpha. These findings could explain other evidence of hypoxia in varicose veins. Finally, results already obtained in this investigation suggest that the process of pathogenesis o...Continue Reading

References

Dec 1, 1989·The Journal of Pathology·C M MilroyJ W Bradfield
Dec 1, 1986·World Journal of Surgery·J Ludbrook
Oct 1, 1994·The British Journal of Surgery·A Abu-OwnP D Coleridge Smith
Jul 1, 1993·Journal of Clinical Pathology·A K Charles, G A Gresham
Feb 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J P TraversT M Mayhew
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A H ChesterM H Yacoub
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·M J Mulvany
Mar 26, 1998·Journal of Cardiovascular Pharmacology·T ArnouldJ Remacle
Jan 1, 1997·Vascular Medicine·P D Coleridge Smith
Jun 4, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M SaharayP D Coleridge Smith
Jul 1, 1998·The Annals of Thoracic Surgery·A H ChesterM H Yacoub
Sep 14, 1999·VASA. Zeitschrift für Gefässkrankheiten·G CiuffettiG Lupattelli
Mar 10, 2001·The Journal of Pathology·C Badier-CommanderM P Jacob
Oct 23, 2002·Journal of Applied Physiology·Eijiro OhgaYasuyoshi Ouchi
Feb 25, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Mahmoud A Wali, Refaat A Eid
Feb 5, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S J HollingsworthD G Cooper
Sep 28, 2005·VASA. Zeitschrift für Gefässkrankheiten·M Aunapuu, A Arend
Dec 6, 2005·Metabolism: Clinical and Experimental·Thomas ReinehrRanier Wunsch

❮ Previous
Next ❯

Citations

May 7, 2013·Journal of Vascular Surgery·Chung S LimAlun H Davies
Jan 27, 2012·Journal of Vascular Surgery·Chung S LimAlun H Davies
Jun 12, 2014·Expert Review of Molecular Diagnostics·Ferdinando MannelloJoseph D Raffetto
Dec 17, 2017·Immunologic Research·Alexandra ShadrinaMaxim Filipenko
Jul 12, 2018·Disease Models & Mechanisms·Spencer A Hobson-Gutierrez, Carlos Carmona-Fontaine
Jun 3, 2020·Scientific Reports·Yoshitaka KubotaNobuyuki Mitsukawa
Mar 23, 2021·Biophysics Reviews·Shirin SaberianpourMohammad Mahdi Kamyar
Jul 27, 2021·Cardiology Research and Practice·Lukasz GwozdzinskiKrzysztof Gwozdzinski
Jul 10, 2021·Journal of the American College of Nutrition·Mandar GawasPrince Chawla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

© 2021 Meta ULC. All rights reserved